3-Chloro-4-[(4-fluorophenyl)methoxy]benzonitrile

Base Information

Chemical Name:3-Chloro-4-[(4-fluorophenyl)methoxy]benzonitrile
CAS No.:5516-26-7
Molecular Formula:C19H13 N O3
Molecular Weight:303.317
Hs Code.:
DSSTox Substance ID:DTXSID10388083
Wikidata:Q82182802

Synonyms:3-chloro-4-[(4-fluorophenyl)methoxy]benzonitrile;5516-26-7;DTXSID10388083;AKOS008719069;A1-05451

Suppliers and Price of 3-Chloro-4-[(4-fluorophenyl)methoxy]benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Chloro-4-[(4-fluorophenyl)methoxy]benzonitrile

Chemical Property:

Vapor Pressure:2.62E-06mmHg at 25°C
Boiling Point:390.6°Cat760mmHg
Flash Point:190°C
Density:1.31g/cm³
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:261.0356698
Heavy Atom Count:18
Complexity:308

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1COC2=C(C=C(C=C2)C#N)Cl)F

Technology Process of 3-Chloro-4-[(4-fluorophenyl)methoxy]benzonitrile

There total 5 articles about 3-Chloro-4-[(4-fluorophenyl)methoxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 131-91-9
1-Nitroso-2-naphthol

: 5516-26-7
4-naphtho[1,2-d][1,3]oxazol-2-yl-benzoic acid methyl ester

Guidance literature:: With potassium carbonate; In tetrahydrofuran; for 12h; Reflux;
DOI:10.1021/ol902812q

Reference yield: 76.0%

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 233-70-5
naphtho[1,2-d]oxazole

: 5516-26-7
4-naphtho[1,2-d][1,3]oxazol-2-yl-benzoic acid methyl ester

Guidance literature:: With iron(III) chloride; 1,10-Phenanthroline; 1,2-dichloro-2-methylpropane; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Sealed tube; Inert atmosphere;
DOI:10.1055/s-0037-1609718