4-(2-(Tetrahydro-2,2-dimethyl-4-phenyl-2H-pyran-4-yl)ethyl)morpholine

Base Information

• Chemical Name: 4-(2-(Tetrahydro-2,2-dimethyl-4-phenyl-2H-pyran-4-yl)ethyl)morpholine
• CAS No.: 130688-23-2
• Molecular Formula: C₁₉H₂₉NO₂
• Molecular Weight: 303.445
• DSSTox Substance ID: DTXSID20926854
• Mol file: 130688-23-2.mol

Synonyms:BRN 4355234;4-(2-(Tetrahydro-2,2-dimethyl-4-phenyl-2H-pyran-4-yl)ethyl)morpholine;Morpholine, 4-(2-(tetrahydro-2,2-dimethyl-4-phenyl-2H-pyran-4-yl)ethyl)-;130688-23-2;4-[2-(2,2-dimethyl-4-phenyloxan-4-yl)ethyl]morpholine;DTXSID20926854;LS-93431

Chemical Property of 4-(2-(Tetrahydro-2,2-dimethyl-4-phenyl-2H-pyran-4-yl)ethyl)morpholine

Chemical Property:

• Vapor Pressure: 9.64E-07mmHg at 25°C
• Boiling Point: 404.2°Cat760mmHg
• Flash Point: 122.8°C
• Density: 1.009g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 303.219829168
• Heavy Atom Count: 22
• Complexity: 345

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(CCO1)(CCN2CCOCC2)C3=CC=CC=C3)C

Technology Process of 4-(2-(Tetrahydro-2,2-dimethyl-4-phenyl-2H-pyran-4-yl)ethyl)morpholine

There total 3 articles about 4-(2-(Tetrahydro-2,2-dimethyl-4-phenyl-2H-pyran-4-yl)ethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-(2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-1-morpholin-4-yl-ethanone (130688-14-1) → 2,2-dimethyl-4-phenyl-4-β-N-morphylylethyltetrahydropyran (130688-23-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 20h; Heating;

DOI:10.1007/BF00766251

Reference yield:

2,2-dimethyl-4-phenyltetrahydropyran-4-ylcarbonyl chloride (130707-29-8) → 2,2-dimethyl-4-phenyl-4-β-N-morphylylethyltetrahydropyran (130688-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 24 h

2: 62 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 20 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;

DOI:10.1007/BF00766251

Reference yield:

(2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetic acid (109878-50-4) → 2,2-dimethyl-4-phenyl-4-β-N-morphylylethyltetrahydropyran (130688-23-2)

Guidance literature:

Multi-step reaction with 3 steps

1: formamide, SOCl₂ / benzene / 1 h / 60 °C

2: diethyl ether / 24 h

3: 62 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 20 h / Heating

With lithium aluminium tetrahydride; thionyl chloride; formamide; In tetrahydrofuran; diethyl ether; benzene;

DOI:10.1007/BF00766251

upstream raw materials:

2-(2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-1-morpholin-4-yl-ethanone

2,2-dimethyl-4-phenyltetrahydropyran-4-ylcarbonyl chloride

(2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetic acid