109878-50-4

Basic information

• Product Name: (2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetic acid
• CAS NO: 109878-50-4
• Molecular Weight: 248.322
• Mol File: 109878-50-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetic acid(109878-50-4)
• EPA Substance Registry System: (2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetic acid(109878-50-4)

Safety Data

• Hazardous Substances Data: 109878-50-4(Hazardous Substances Data)

Usage

General Description

"(2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetic acid" is a chemical compound that belongs to the class of carboxylic acids. It has a molecular formula of C15H20O3 and a molecular weight of 248.32 g/mol. (2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetic acid is a derivative of tetrahydro-pyran, which is a six-membered heterocyclic ring containing five carbon atoms and one oxygen atom. The presence of the phenyl and acetic acid groups in the molecule suggests potential pharmaceutical and synthetic uses. However, further research is needed to fully understand its properties and potential applications.

Upstream product

• 1194-16-7 2,2-dimethyltetrahydropyran-4-one 
• 109878-46-8 (2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetonitrile 
• 109878-42-4 Cyano-(2,2-dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-acetic acid ethyl ester 
• 64792-49-0 Ethyl (2,2-dimethyl-4-tetrahydropyranylidene)cyanoacetate 

Downstream Products

• 130688-23-2 2,2-dimethyl-4-phenyl-4-β-N-morphylylethyltetrahydropyran 
• 130688-22-1 2,2-dimethyl-4-benzyl-4-β-N-piperidylethyltetrahydropyran 
• 130688-20-9 2,2-dimethyl-4-phenyl-4-β-N-pyrrolidylethyltetrahydropyran 
• 126317-99-5 2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethanamine 
• 130707-30-1 2,2-dimethyl-4-phenyl-4-aminomethyltetrahydropyran 
• 130688-14-1 2-(2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-1-morpholin-4-yl-ethanone 
• 130688-15-2 2-(2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-1-piperidin-1-yl-ethanone 
• 130688-16-3 2-(2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-1-pyrrolidin-1-yl-ethanone 
• 130688-11-8 2,2-dimethyl-4-phenyltetrahydropyran-4-ylacetamide 

Relevant articles and documents

Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT)

A series of tetrahydropyranyl (THP) derivatives has been developed as potent inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) for use as anticancer agents. Structural modification of the submicromolar hit compound 3 led to the potent 3-methoxy substituted analogue 27. Further SAR development around the THP ring resulted in an additional 10-fold increase in potency, exemplified by analogue 75 with an IC50 of 1.3 nM. Active and potent compounds demonstrated a dose-dependent increase in Ras cytosolic protein. Potent ICMT inhibitors also reduced cell viability in several cancer cell lines with growth inhibition (GI50) values ranging from 0.3 to >100 μM. However, none of the cellular effects observed using ICMT inhibitors were as pronounced as those resulting from a farnesyltransferase inhibitor.