((E)-4-((1R,2S)-2-(tert-Butyldimethylsilyl)oxycyclohexyl)-2-methylbut-2-enyl) 2,4-dichlorobenzoate

Base Information

Chemical Name:((E)-4-((1R,2S)-2-(tert-Butyldimethylsilyl)oxycyclohexyl)-2-methylbut-2-enyl) 2,4-dichlorobenzoate
CAS No.:101859-34-1
Molecular Formula:C24H36 Cl2 O3 Si
Molecular Weight:471.5323
Hs Code.:

Synonyms:((E)-4-((1R,2S)-2-(tert-Butyldimethylsilyl)oxycyclohexyl)-2-methylbut-2-enyl) 2,4-dichlorobenzoate;101859-34-1;Benzoic acid, 2,4-dichloro-, 4-(2-(((1,1- dimethylethyl)dimethylsilyl)oxy)cyclohexyl)-2-methyl-2-butenyl ester, (1alpha(E),2beta)-

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((E)-4-((1R,2S)-2-(tert-Butyldimethylsilyl)oxycyclohexyl)-2-methylbut-2-enyl) 2,4-dichlorobenzoate

Chemical Property:

Vapor Pressure:3.84E-10mmHg at 25°C
Boiling Point:500.3°Cat760mmHg
Flash Point:256.4°C
Density:1.1g/cm³
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:470.1810769
Heavy Atom Count:30
Complexity:600

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=CCC1CCCCC1O[Si](C)(C)C(C)(C)C)COC(=O)C2=C(C=C(C=C2)Cl)Cl
Isomeric SMILES:C/C(=C\C[C@H]1CCCC[C@@H]1O[Si](C)(C)C(C)(C)C)/COC(=O)C2=C(C=C(C=C2)Cl)Cl

Technology Process of ((E)-4-((1R,2S)-2-(tert-Butyldimethylsilyl)oxycyclohexyl)-2-methylbut-2-enyl) 2,4-dichlorobenzoate

There total 6 articles about ((E)-4-((1R,2S)-2-(tert-Butyldimethylsilyl)oxycyclohexyl)-2-methylbut-2-enyl) 2,4-dichlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 101859-31-8
(1R*,2S*,(2E))-2-((tert-butyldimethylsilyl)oxy)cyclohexane-3-methyl-2-buten-4-ol

: 89-75-8
2,4-dichlorobenzoyl chloride

: 101859-34-1
2,4-Dichloro-benzoic acid (E)-4-[(1S,2R)-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-methyl-but-2-enyl ester

Guidance literature:: With dmap; TEA; In dichloromethane;
DOI:10.1021/jo00362a014

Reference yield:

: 74708-24-0,74708-25-1,90242-33-4,101976-91-4,74629-88-2
(1R*,2S*)-2-hydroxycyclohexane acetonitrile

: 101859-34-1
2,4-Dichloro-benzoic acid (E)-4-[(1S,2R)-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / TEA, DMAP / tetrahydrofuran; dimethylformamide

2: 86 percent / dibal / toluene / -78 - 0 °C

3: 90 percent / CHCl₃ / Heating

4: 94 percent / dibal / toluene / -78 - 0 °C

5: 90 percent / TEA, DMAP / CH₂Cl₂

With dmap; TEA; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00362a014

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 101859-34-1
2,4-Dichloro-benzoic acid (E)-4-[(1S,2R)-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / tetrahydrofuran / 0 °C

2: 88 percent / TEA, DMAP / tetrahydrofuran; dimethylformamide

3: 86 percent / dibal / toluene / -78 - 0 °C

4: 90 percent / CHCl₃ / Heating

5: 94 percent / dibal / toluene / -78 - 0 °C

6: 90 percent / TEA, DMAP / CH₂Cl₂

With dmap; TEA; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00362a014