Technology Process of Neooncinotine
There total 9 articles about Neooncinotine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium formate;
palladium dihydroxide;
In
ethanol;
for 19h;
Heating;
DOI:10.1021/jo049526i
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 82 percent / 1,3-diisopropylcarbodiimide / CH2Cl2 / 24 h / 20 °C
2: 87 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating
3: 85 percent / triethylamine / CH2Cl2 / 1 h / 0 °C
4: 68 percent / HCl / Grubbs catalyst / CH2Cl2 / 24 h / Heating
5: 99 percent / HCl; H2 / Pd/C / methanol / 5 h / 15200 Torr
6: 70 percent / ammonium formate / Pd(OH)2/C / ethanol / 19 h / Heating
With
hydrogenchloride; lithium aluminium tetrahydride; hydrogen; ammonium formate; triethylamine; diisopropyl-carbodiimide;
palladium dihydroxide; palladium on activated charcoal; Grubbs catalyst first generation;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jo049526i
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 85 percent / triethylamine / CH2Cl2 / 1 h / 0 °C
2: 68 percent / HCl / Grubbs catalyst / CH2Cl2 / 24 h / Heating
3: 99 percent / HCl; H2 / Pd/C / methanol / 5 h / 15200 Torr
4: 70 percent / ammonium formate / Pd(OH)2/C / ethanol / 19 h / Heating
With
hydrogenchloride; hydrogen; ammonium formate; triethylamine;
palladium dihydroxide; palladium on activated charcoal; Grubbs catalyst first generation;
In
methanol; ethanol; dichloromethane;
DOI:10.1021/jo049526i
