768370-03-2

Upstream product

• 768370-01-0 4-oxo-4-(2-allylpiperidino)butyric acid 
• 103-49-1 dibenzylamine 
• 71121-96-5 2-(3-(dibenzylamino)propyl)isoindoline-1,3-dione 
• 107142-94-9 1-Amino-3-dibenzylaminopropane 
• 768370-02-1 N-(3-dibenzylaminopropyl)-4-oxo-4-(2-allylpiperidinyl)butyramide 

Downstream Products

• 768370-05-4 dec-9-enoic acid [4-(2-allyl-piperidin-1-yl)-butyl]-(3-dibenzylamino-propyl)-amide 
• 62107-29-3 neooncinotine 
• 62074-29-7 9-(3-dibenzylamino-propyl)-octadecahydro-4a,9-diaza-benzocyclooctadecen-10-one 
• 768370-06-5 9-(3-dibenzylamino-propyl)-1,3,4,6,7,8,9,11,12,13,14,15,16,17,20,20a-hexadecahydro-2H,5H-4a,9-diaza-benzocyclooctadecen-10-one 

Relevant academic research and scientific papers

Efficient syntheses of oncinotine and neooncinotine

We have synthesized two natural alkaloids, oncinotine (1) and neooncinotine (2), by means of efficient ring-closing metathesis (RCM) reactions. The required dienes for RCM were assembled from three basic components: 2-allylpiperidine (5), 9-decenoic acid (6), and diamines 7. We developed two different methods to achieve the linkage: the Michael addition of acrylamide and two amidations of succinic anhydride. The Grubbs catalyst was used to form the 17- and 18-membered lactams in 50% and 68% yields, respectively.