(2-Methylquinolin-3-yl)methanol

Base Information

• Chemical Name: (2-Methylquinolin-3-yl)methanol
• CAS No.: 53936-95-1
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.214
• NSC Number: 165994
• DSSTox Substance ID: DTXSID30304503
• Nikkaji Number: J1.249.619B
• Wikidata: Q82050445
• Mol file: 53936-95-1.mol

Synonyms:(2-methylquinolin-3-yl)methanol;53936-95-1;NSC165994;3-Hydroxymethylquinaldine;SCHEMBL3633495;DTXSID30304503;(2-Methyl-3-quinolinyl)methanol #;NSC-165994;EN300-5103337;Z1255417752

Chemical Property of (2-Methylquinolin-3-yl)methanol

Chemical Property:

• Vapor Pressure: 6.24E-05mmHg at 25°C
• Boiling Point: 331.4°Cat760mmHg
• Flash Point: 154.2°C
• Density: 1.179g/cm³
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 173.084063974
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2C=C1CO

Technology Process of (2-Methylquinolin-3-yl)methanol

There total 17 articles about (2-Methylquinolin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methyl-3-carbethoxyquinoline (15785-08-7) → 3-(hydroxymethyl)-2-methylquinoline (53936-95-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h; Cooling with ice;

DOI:10.1002/adsc.201601423

Reference yield: 95.0%

methyl 2-methylquinoline-3-carboxylate (30160-03-3) → 3-(hydroxymethyl)-2-methylquinoline (53936-95-1)

Guidance literature:

With diisobutylaluminium hydride; at -78 ℃;

DOI:10.1016/j.tetlet.2007.06.100

Reference yield: 80.0%

3-(acetoxymethyl)-2-methylquinoline (460316-14-7) → 3-(hydroxymethyl)-2-methylquinoline (53936-95-1)

Guidance literature:

With potassium carbonate; In methanol; water; at 20 ℃;

DOI:10.1016/S0040-4020(02)00332-0

upstream raw materials:

methyl 2-methylquinoline-3-carboxylate

2-methyl-3-carbethoxyquinoline

3-(acetoxymethyl)-2-methylquinoline

o-aminobenzaldehyde

Downstream raw materials:

3-ethoxy-1,3-dihydrofuro[4,3-b]quinoline

2-hydroxymethyl-quinolin-3-yl-methanol