15785-08-7Relevant articles and documents
TBAHS-catalyzed synthesis of 2-dihydroquinazolin-2-ylquinoline: An efficient and practical synthesis of naturally occurring alkaloids luotonin A, B, and e
Nagarapu, Lingaiah,Gaikwad, Hanmant K.,Bantu, Rajashaker
, p. 1775 - 1778 (2012)
A synthesis of 2-dihydroquinazolin-2-ylquinoline using a phase-transfer catalyst (TBAHS) in semi-aqueous phase, followed by Mitsunobu cyclization as key steps for an efficient and practical synthesis of naturally occurring alkaloids luotonin A, B, and E starting from o-nitrobenzaldehyde is reported. The new approach presents the advantage of a shorter route with high overall yield (57%, 45%, and 37%, respectively) and ease of operation.
Practical route to a β-ketophosphonate, a key intermediate for the total synthesis of 20(S)-CPT and related analogues
Huo, Ming,Kuang, Yun-Yan,Chen, Fen-Er
, p. 331 - 335 (2004)
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Palladium(II)-Catalyzed ortho-Arylation of Aromatic Alcohols with a Readily Attachable and Cleavable Molecular Scaffold
Li, Qiankun,Knight, Brian J.,Ferreira, Eric M.
, p. 13054 - 13058 (2016)
A palladium(II)-catalyzed C?H arylation process of alcohols has been developed. The strategy utilizes a novel quinoline-based hemiacetal scaffold that can direct the selective C?H bond functionalization. This reaction provides a useful method to construct biaryl compounds of benzyl alcohols in good to excellent yields. The new molecular scaffold can be readily attached, removed, and recovered.
An efficient heterogeneous gold(I)-catalyzed intermolecular cycloaddition of 2-aminoaryl carbonyls and internal alkynes leading to polyfunctionalized quinolines
Hu, Wenli,Yang, Weisen,Yan, Tao,Cai, Mingzhong
supporting information, p. 799 - 813 (2019/03/23)
The first heterogeneous intermolecular cycloaddition of 2-aminoaryl carbonyls and internal alkynes was realized in DMF at 100 °C by using a triphenylphosphine-functionalized MCM-41-supported gold(I) complex [MCM-41-PPh3-AuCl] and AgOTf as catal
Synthesis of Polysubstituted Quinolines from α-2-Aminoaryl Alcohols Via Nickel-Catalyzed Dehydrogenative Coupling
Das, Sanju,Maiti, Debabrata,De Sarkar, Suman
, p. 2309 - 2316 (2018/02/23)
This study reports a nickel-catalyzed sustainable synthesis of polysubstituted quinolines from α-2-aminoaryl alcohols by a sequential dehydrogenation and condensation process that offers the advantages of a low catalyst loading and wide substrate scope. In contrast to earlier reported methods, this strategy allows the use of both primary as well as secondary α-2-aminoaryl alcohols in combination with either ketones or secondary alcohols for desired product formation. Using this methodology, 30 substituted quinoline derivatives were synthesized with up to 93% isolated yields.
