leualacin

Base Information

• Chemical Name: leualacin
• CAS No.: 128140-12-5
• Molecular Formula: C₃₁H₄₇N₃O₇
• Molecular Weight: 573.73
• Mol file: 128140-12-5.mol

Synonyms:Cyclo(b-alanyl-4-methyl-D-2-hydroxypentanoyl-L-leucyl-4-methyl-L-2-hydroxypentanoyl-N-methyl-L-phenylalanyl);1,7-Dioxa-4,10,13-triazacyclohexadecane, cyclic peptide deriv.; Leualacin

Chemical Property of leualacin

Chemical Property:

• Vapor Pressure: 4.92E-22mmHg at 25°C
• Boiling Point: 724.5°Cat760mmHg
• Flash Point: 392°C
• Density: 1.159g/cm³

Purity/Quality:

LEUALACIN 95.00% ^*data from reagent suppliers

Safty Information:

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Technology Process of leualacin

There total 30 articles about leualacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-2-Amino-4-methyl-pentanoic acid (S)-3-methyl-1-(methyl-{(S)-1-[2-((R)-3-methyl-1-pentafluorophenyloxycarbonyl-butoxycarbonyl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamoyl)-butyl ester → leualacin (128140-12-5)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; for 5h; Ambient temperature;

DOI:10.1039/c39940002381

Reference yield: 69.0%

H-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe-OH (168069-98-5) → leualacin (128140-12-5)

Guidance literature:

With diphenyl-phosphinic acid; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 ℃; for 72h;

DOI:10.1021/jo00124a019

Reference yield: 60.0%

(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-(methyl-{(S)-1-[2-((R)-3-methyl-1-pentafluorophenyloxycarbonyl-butoxycarbonyl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamoyl)-butyl ester → leualacin (128140-12-5)

Guidance literature:

With pentafluorophenyl diphenyl-phosphinate; In N,N-dimethyl-formamide; for 18h;

DOI:10.1039/c39940002381

upstream raw materials:

H-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe-OH

(R)-leucine

L-leucine

(R)-2-hydroxy-4-methylpentanoic acid

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