DL-Leucine

Base Information

• Chemical Name: DL-Leucine
• CAS No.: 328-38-1
• Deprecated CAS: 1105707-16-1
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Hs Code.: 2922.49
• European Community (EC) Number: 206-328-2
• NSC Number: 77687,46709,9252
• UNII: 1QSS9D5DR6
• DSSTox Substance ID: DTXSID00859050
• Nikkaji Number: J1.285H
• Wikidata: Q60662890
• Metabolomics Workbench ID: 1872
• ChEMBL ID: CHEMBL46575
• Mol file: 328-38-1.mol

Synonyms:DL-Leucine;328-39-2;2-Amino-4-methylpentanoic acid;H-DL-Leu-OH;Leucine, DL-;(RS)-Leucine;(+-)-Leucine;25322-63-8;MFCD00063087;2-amino-4-methyl-pentanoic acid;NSC46709;(+/-)-Amino-4-methylpentanoic acid;UNII-1QSS9D5DR6;1QSS9D5DR6;DL-LEUCINE (15N);CHEBI:25017;L-LEUCINE (U-13C6);L-LEUCINE-1-13C-15N;NSC 9252;NSC-9252;EINECS 206-328-2;( inverted exclamation markA)-Leucine;73579-45-0;AI3-26709;Leuzin;DL-LEUCINE-4,5,5,5,6,6,6-D7;Hleu;L(+)-Leucine;DL-2-Amino-4-methylpentanoic acid;Norvaline, 4-methyl-;2-amino-4-methylpentanoicacid;NSC9252;Valeric acid, 2-amino-4-methyl-;laevo-leucine;MFCD00002617;MFCD00063088;NSC-77687;d,l-leucine;3h-leucine;DL- leucine;d,1-leucine;Leucine #;.alpha.-Amino-.gamma.-methylvaleric acid;92751-17-2;(.+-.)-Leucine;(.+/-.)-Leucine;Leu247;LEUCINE,(L);DL-LEUCINE [FCC];SCHEMBL3888;.alpha.-Aminoisocaproic acid;CHEMBL46575;WLN: QVYZ1Y1&1 -L;2-amino-4-methyl pentanoic acid;DTXSID00859050;WLN: QVYZ1Y1 & 1-D;DL-Leucine, >=99% (HPLC);271247-12-2;HY-B1674;NSC77687;(2R)-2-ammonio-4-methylpentanoate;Pentanoic acid, 2-amino-4-methyl-;AC7886;DL-2-Aminmo-4-methylvalerianic acid;LMFA01100048;STL281857;AKOS000118923;AKOS016050505;CS-W020700;PB47827;7005-03-0;AC-24099;AS-12287;LS-87802;NCI60_004103;SY005863;SY006365;SY033229;AM20090485;DL-Leucine, Vetec(TM) reagent grade, 99%;FT-0602784;FT-0625480;FT-0627930;FT-0641848;FT-0670765;FT-0695062;FT-0695813;FT-0770717;FT-0771371;L0028;(+/-)-2-AMINO-4-METHYLVALERIC ACID;EN300-18048;A817787;A821451;SR-01000944477;Q-100404;SR-01000944477-1;L-Leucine-15N;H-[15N]LEU-OH;59935-31-8;Q60662890;Z57127546;F2191-0181;8EB2668C-D303-4401-A7D5-8ABD6B79B75F;25988-64-1

Chemical Property of DL-Leucine

Chemical Property:

• Appearance/Colour: white crystals
• Vapor Pressure: 0.0309mmHg at 25°C
• Melting Point: 300 ºC
• Refractive Index: -15 ° (C=4, 6mol/L HCl)
• Boiling Point: 225.8 ºC at 760 mmHg
• PKA: 2.55±0.21(Predicted)
• Flash Point: 90.3 ºC
• PSA: 63.32000
• Density: 1.035 g/cm³
• LogP: 1.14470
• Storage Temp.: -15°C
• Solubility.: Aqueous Acid (Sparingly), Water (Slightly)
• Water Solubility.: 24 g/L (25 ºC)
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

min 99% ^*data from raw suppliers

D-Leucine, 99+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)N
• Uses: D-Leucine is used in the formation of sterols. It is also used as a selectable marker.

Technology Process of DL-Leucine

There total 121 articles about DL-Leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pholipeptin → D-Serine (312-84-5,83245-15-2) + L-threonine (72-19-5,134357-96-3,7013-32-3,82822-12-6) + (R)-leucine (328-38-1,21675-61-6,25248-98-0,70-45-1) + L-isoleucine (73-32-5,959215-79-3,18875-42-8) + (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3)

Guidance literature:

With hydrogenchloride; at 120 ℃; for 20h; Product distribution;

DOI:10.1021/jo9603993

Reference yield:

des-thiomethyllooekeyolide A → (2S)-2-hydroxybutanoic acid (3347-90-8) + (R)-leucine (328-38-1,21675-61-6,25248-98-0,70-45-1)

Guidance literature:

With hydrogenchloride; In water; at 115 ℃; for 18h; Sealed tube;

DOI:10.1021/acs.jnatprod.8b00804

Reference yield:

L-Met-D-Leu (1172640-74-2) → (R)-leucine (328-38-1,21675-61-6,25248-98-0,70-45-1) + L-methionine (63-68-3,26062-47-5,58576-49-1)

Guidance literature:

With recombinant Streptomyces coelicolor Sco₃₀₅₈ dipeptidase; water; at 30 ℃; pH=8; Concentration; Kinetics; aq. buffer; Enzymatic reaction;

DOI:10.1021/bi901935y

upstream raw materials:

LEUCINE

DL-leucine ethyl ester

N-formyl-valine

N-formyl-D-leucine

Downstream raw materials:

N-[(2,4,5-trichloro-phenoxy)-acetyl]-D-leucine

(R)-2-hydroxy-4-methylpentanoic acid

N-[(2,4-Dichlor-phenoxy)-acetyl]-D-leucin

N-[(4-chloro-phenoxy)-acetyl]-D-leucine

Refernces

• 1、 Chen, Min,Chen, Rouwen,Ding, Wenping,Li, Yanqun,Tian, Xinpeng,Yin, Hao,Zhang, Si. "Structures and antitumor activities of ten new and twenty known surfactins from the deep-sea bacterium Limimaricola sp. SCSIO 53532". . . Retrieved 2022/01/11.
• 2、 Shin, Yern-Hyerk,Ban, Yeon Hee,Kim, Tae Ho,Bae, Eun Seo,Shin, Jongheon,Lee, Sang Kook,Jang, Jichan,Yoon, Yeo Joon,Oh, Dong-Chan. "Structures and Biosynthetic Pathway of Coprisamides C and D, 2-Alkenylcinnamic Acid-Containing Peptides from the Gut Bacterium of the Carrion Beetle Silpha perforata". . . Retrieved 2021/02/26.