2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI)

Base Information

• Chemical Name: 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI)
• CAS No.: 15932-71-5
• Molecular Formula: C₈H₁₄N₂O
• Molecular Weight: 154.212
• Hs Code.: 2933990090
• Mol file: 15932-71-5.mol

Synonyms:Hexahydro-2H-pyrido[1,2-a]pyrazin-1(6H)-one

Chemical Property of 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.000177mmHg at 25°C
• Boiling Point: 329.5°Cat760mmHg
• Flash Point: 153.1°C
• PSA: 35.83000
• Density: 1.13g/cm³
• LogP: 0.18450

Purity/Quality:

99% ^*data from raw suppliers

octahydro-1H-pyrido[1,2-a]piperazin-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI)

There total 7 articles about 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-Hydroxyethyl)phthalimide (3891-07-4) + ethyl piperidine-2-carboxylate hydrochloride (77034-33-4) → 2H-octahydropyrido<1,2-a>pyrazin-1-one (15932-71-5,22328-79-6,22328-80-9)

Guidance literature:

N-(2-Hydroxyethyl)phthalimide; With trifluoromethylsulfonic anhydride; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

ethyl piperidine-2-carboxylate hydrochloride; Further stages;

DOI:10.1002/anie.201408609

Reference yield:

ethyleneimine (151-56-4,9002-98-6) + methyl pyridine-2-carboxylate (2459-07-6,260998-83-2) → 2H-octahydropyrido<1,2-a>pyrazin-1-one (15932-71-5,22328-79-6,22328-80-9)

Guidance literature:

In ethanol;

Reference yield:

pipecolic Acid (4043-87-2,83680-83-5) → 2H-octahydropyrido<1,2-a>pyrazin-1-one (15932-71-5,22328-79-6,22328-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 4 h / 0 - 90 °C / Inert atmosphere

2.1: trifluoromethylsulfonic anhydride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 0.17 h / 0 °C / Inert atmosphere

With thionyl chloride; trifluoromethylsulfonic anhydride; In dichloromethane;

DOI:10.1002/anie.201408609

upstream raw materials:

1-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-piperidine-2-carboxylic acid ethyl ester

ethyl pipecolate

ethyleneimine

methyl pyridine-2-carboxylate

Downstream raw materials:

2-(4-nitrophenyl)octahydro-2H-pyrido[1,2-a]pyrazine

4-(octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)phenylamine

octahydro-1H-pyrido[1,2-a]pyrazine

2-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-hexahydro-pyrido[1,2-a]pyrazin-1-one

Refernces

• 1、 H?glund, Iisa P. J.,Silver, Satu,Engstr?m, Mia T.,Salo, Harri,Tauber, Andrei,Kyyr?nen, Hanna-Kaisa,Saarenketo, Pauli,Hoffrén, Anna-Marja,Kokko, Kurt,Pohjanoksa, Katariina,Sallinen, Jukka,Savola, Juha-Matti,Wurster, Siegfried,Kallatsa, Oili A.. "Structure-activity relationship of quinoline derivatives as potent and selective α2c-adrenoceptor antagonists". . p. 6351 - 6363. Retrieved 2007/10/03.
• 2、 -. "2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use". . . Retrieved 2008/06/13.