3891-07-4Relevant articles and documents
Microgels as Matrices for Molecular Receptor and Reactive Sites: Synthesis and Reactivity of Cavities possessing Amino-functions
Hopkins, Andrew,Williams, Andrew
, p. 891 - 896 (1983)
Non-fluxional polymeric particles, microgels, have been prepared containing amino-functions situated in cavities in the polymer matrix.The microgels possess binding properties and exhibit greatly enhanced rates of reaction versus isoquinoline-N-sulphonate and 4-nitrophenyl ester substrates compared with simple amines.The polymer reagents possess selectivity against the molecular size of the substrate due to finite cavity size and this selectivity may be modified by variation of pH which causes a change in size of the cavities.
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Wenker
, p. 422 (1937)
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Novel synthesis method of N-hydroxyethyl phthalimide
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Paragraph 0014-0023, (2021/09/04)
The invention discloses a novel synthesis method of N-hydroxyethyl phthalimide, which comprises: by taking phthalimide and ethylene oxide as substrates, carrying out nucleophilic substitution reaction to enable the ethylene oxide to be subjected to ring opening, so as to prepare the N-hydroxyethyl phthalimide. According to the method, N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC) is taken as a solvent, phthalimide and ethylene oxide are directly heated at 100-160 DEG C to react, the temperature is kept to react for a period of time, and then cooling and simple filtering are performed to obtain the N-hydroxyethyl phthalimide with the content of more than 99%. The molar yield can reach 97% or above. No by-product is generated in the whole synthesis production process; after being filtered, the solvent can be applied to the next batch of reaction without treatment, and no process waste is generated in the whole process, so that zero emission of organic synthesis is really realized, and the purpose of clean production is achieved.
FLUORINATED BENZO[F]BENZIMIDAZOL-4-9-DIONE IUM DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE AS SURVIVIN SUPPRESSANTS
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Paragraph 00176; 00178, (2020/09/30)
The present application relates to novel fluorinated derivatives, to processes for their preparation, to compositions comprising them, and to their use in therapy. More specifically, it relates to compounds useful in the treatment of diseases, disorders or conditions mediated by survivin inhibition. In particular, the present application includes compounds of Formula (I) or (II), and compositions and uses thereof: (Formulae (I) (II)).
Synthesis process of amlodipine besylate
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Paragraph 0006; 0014; 0015; 0018; 0019, (2018/09/14)
The invention discloses a synthesis process of amlodipine besylate, relates to the technical field of medicine synthesis and solves the problems of low product purity and poor product quality controllability of products prepared by the existing synthesis process. According to the synthesis process, phthalic anhydride is used as raw materials; the parameters of the synthesis process are controlled;the technical flow process is shortened; the synthesis cost is reduced; the product yield is as high as 91 percent; the purity of the prepared amlodipine besylate is as high as 99.5 percent. The self-made amlodipine besylate are used as raw materials for further preparing the amlodipine besylate tablets; the product cost is reduced; the product quality controllability is high.
