ADENOSINE AMINE CONGENER (ADAC)

Base Information

• Chemical Name: ADENOSINE AMINE CONGENER (ADAC)
• CAS No.: 96760-69-9
• Molecular Formula: C28H32N8O6
• Molecular Weight: 576.612
• Mol file: 96760-69-9.mol

Synonyms:Adenosine amine congener hydrate;Adenosine Amine Congener;

Chemical Property of ADENOSINE AMINE CONGENER (ADAC)

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 13.11±0.70(Predicted)
• Flash Point: °C
• PSA: 209.77000
• Density: 1.56g/cm³
• LogP: 1.21720
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: 0.1 M acetic acid: 12 mM

Purity/Quality:

98%Min ^*data from raw suppliers

Adenosine amine congener hydrate solid, ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of ADENOSINE AMINE CONGENER (ADAC)

There total 5 articles about ADENOSINE AMINE CONGENER (ADAC) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N6-<4-<<<<4-<<(Methyloxy)carbonyl>methyl>phenyl>amino>carbonyl>methyl>phenyl>adenosine (96760-66-6) + ethylenediamine (107-15-3,85404-18-8) → N-(4-(2-((4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)amino)-2-oxoethyl)phenyl)adenosine (96760-69-9)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1021/jm00147a038

Reference yield:

4-aminophenylacetic acid (1197-55-3) → N-(4-(2-((4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)amino)-2-oxoethyl)phenyl)adenosine (96760-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / HCl gas / 4 h

2: 66 percent / EDAC, 1-hydroxybenzotriazole, N-ethylmorpholine / dimethylformamide / 2 h / Ambient temperature

3: 96 percent / dimethylformamide

With N-ethylmorpholine;; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00147a038

Reference yield:

6-Chloropurine riboside (2004-06-0) → N-(4-(2-((4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)amino)-2-oxoethyl)phenyl)adenosine (96760-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / triethylamine / ethanol; H₂O / 72 h / 80 °C

2: 66 percent / EDAC, 1-hydroxybenzotriazole, N-ethylmorpholine / dimethylformamide / 2 h / Ambient temperature

3: 96 percent / dimethylformamide

With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00147a038

upstream raw materials:

N⁶-<4-<<<<4-<<(Methyloxy)carbonyl>methyl>phenyl>amino>carbonyl>methyl>phenyl>adenosine

ethylenediamine

4-aminophenylacetic acid

6-Chloropurine riboside

Downstream raw materials:

N⁶-<4-<<<4-<<<<2-<(Bromoacetyl)amino>ethyl>amino>carbonyl>methyl>anilino>carbonyl>methyl>phenyl>adenosine

N-(2-{2-[4-(2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-acetylamino)-phenyl]-acetylamino}-ethyl)-3-(4-hydroxy-phenyl)-propionamide

4-(2-Carboxyethylphenylaminothiocarbonyl)-ADAC

N⁶-<4-<<<4-<<<(2-Isothiocyanatoethyl)amino>carbonyl>methyl>anilino>carbonyl>methyl>phenyl>adenosine

Refernces