10.1021/ac034876a
The study presents the development of a biosensor-based assay for the quantification of riboflavin (Rf) in milk samples using surface plasmon resonance (SPR) technology. The assay involves the indirect measurement of Rf by detecting the excess of riboflavin binding protein (RBP) that remains free after complexation with Rf molecules originally present in the sample. The sensor chip is modified with covalently immobilized Rf to bind the excess RBP. The method involves a chemical modification to introduce a reactive ester group on the Rf molecule for immobilization on the chip surface. Calibration solutions are prepared by mixing Rf standard solutions with an optimized concentration of RBP, and the Rf content in milk samples is measured by comparing the response against the calibration. The results are comparable to those obtained from an official HPLC-fluorescence procedure, with a limit of quantification determined to be 234 μg/L and a limit of detection to 70 μg/L. The study demonstrates the potential of SPR-based biosensors as a competitive alternative to traditional analytical techniques for the determination of riboflavin in food samples.
10.1080/17415993.2010.533772
The study investigates the reactions of 2-(4,5-dihydrothiazol-2-ylthio)-1-arylethanone with various nucleophiles, including semicarbazide hydrochloride, hydroxylamine hydrochloride, hydrazine, ethylenediamine, and aminoethanol, to form a range of products selective to the reagents used. The purpose of these reactions is to synthesize heterocyclic compounds containing selenium and sulfur, which are of interest due to their potential applications in the preparation of alkynes and their pharmacological properties, such as antifungal and antibacterial activities. The study explores the formation of different products with different nucleophiles, highlighting the selective nature of the reactions and the resulting compounds' structures, which were confirmed through techniques like single-crystal X-ray analysis.
10.1007/BF00484356
The research focuses on the development of synthetic methods for alkane and cyclohexane derivatives featuring two heterocyclic substituents from the furan, pyrrole, and thiophene series. These compounds, which contain two five-membered aromatic heterorings with one heteroatom, are prevalent in natural compounds but have not been extensively synthesized. The study explores the electrophilic addition of monocarboxylic acid chlorides and dicarboxylic acid dichlorides to allyl or methallyl chlorides, leading to the synthesis of bisfuran, bispyrrole, and bisthiophene derivatives. Key chemicals used in the process include adipic and cyclohexane-1,4-dicarboxylic acid dichlorides, allyl or methallyl chlorides, aluminum chloride, primary amines, phosphorus pentasulfide, and ethylenediamine. The conclusions of the research highlight the successful development of simple and convenient preparative methods for synthesizing a range of these heterocyclic derivatives, which were confirmed through spectral data and chemical transformations.
10.1055/s-0030-1258365
The study presents the development and application of a polystyrene-supported zinc bromide-ethylenediamine complex as a reusable and highly efficient heterogeneous catalyst for the synthesis of α,β-acetylenic ketones. This catalyst enables the rapid and efficient synthesis of these ketones through the cross-coupling of acid chlorides with terminal alkynes, yielding good-to-excellent results. The chemicals used in the study include chloromethylated polystyrene, ethylenediamine, zinc(II) bromide, various acid chlorides, and terminal alkynes. The purpose of these chemicals is to create a catalyst that can be easily prepared, is stable, reusable, and efficient under the reaction conditions, and to synthesize α,β-acetylenic ketones, which are important intermediates in organic synthesis with applications as three-carbon building blocks for the synthesis of heterocycles. The study highlights the advantages of using heterogeneous catalysts in coupling reactions, such as waste reduction and ease of catalyst recovery and reuse, contributing to a simpler and more eco-friendly experimental procedure.
10.1016/j.jinorgbio.2011.03.005
The research focuses on the synthesis, characterization, and evaluation of the cytotoxic activity of a series of cobalt(II) β-ketoaminato complexes towards various human tumor cell lines. The purpose of the study was to investigate the potential of these cobalt compounds as novel cytotoxic drugs, selective towards certain types of tumors. The researchers prepared a series of square planar cobalt(II) compounds with tetradentate β-ketoaminato ligands, varying in the number of ―CF3 ligand substituents, and one tetrahedral cobalt compound with two bidentate ligands. The compounds were synthesized using a multistep reaction sequence involving chemicals such as CoCl2, sodium bis(trimethylsilyl)amide, sodium hydride, tert-butyldimethylchlorosilane, 1,2-diaminoethane, and various β-diketones, including hexafluoroacetylacetone and 4,4,4-trifluoro-1-phenyl-1,3-butanedione. The conclusions drawn from the study indicate that the cobalt complexes, particularly L2Co, exhibit significant cytotoxic activity against prostate cancer and leukemia cells, with activity mediated through mechanisms involving caspase-3, MAP kinases, and reactive oxygen species. These findings suggest that these cobalt complexes could be developed as a new class of cytotoxic drugs.
10.1021/jo00308a030
The study focuses on the synthesis of 1,4-dinitroanthracene-9,10-dione (2) and its subsequent transformations using various diamines. The researchers explored two methods for synthesizing 2, one involving trifluoroacetic anhydride and hydrogen peroxide, and the other using trifluoroacetic acid and hydrogen peroxide. They then investigated the displacement of the nitro groups in 2 by different diamines, such as N,N-dimethylethylenediamine, 2-[(2-aminoethyl)amino]ethanol, and ethylenediamine, to produce monosubstituted and bis-substituted anthracene-9,10-dione derivatives. The study also examined the sequential displacements of the nitro substituents by diamines to prepare unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones. The products were characterized using various analytical techniques, including melting point determination, proton NMR, and mass spectrometry.
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