Zatebradine

Base Information

• Chemical Name: Zatebradine
• CAS No.: 85175-67-3
• Molecular Formula: C26H36 N2 O5
• Molecular Weight: 456.582
• Mol file: 85175-67-3.mol

Synonyms:Zatebradine

Chemical Property of Zatebradine

Chemical Property:

• Vapor Pressure: 6.09E-15mmHg at 25°C
• Boiling Point: 612.5°C at 760 mmHg
• PKA: 8.99±0.50(Predicted)
• Flash Point: 324.3°C
• PSA: 60.47000
• Density: 1.115g/cm³
• LogP: 3.15070
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Zatebradine >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Therapeutic Function: Bradycardic

Technology Process of Zatebradine

There total 14 articles about Zatebradine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine (36770-74-8) + 7,8-dimethoxy-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine (20925-64-8) → zatebradine (85175-67-3)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 50 ℃; for 2h;

DOI:10.1016/S0040-4039(03)00919-5

Reference yield:

1-[7,8dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane (85175-60-6) → zatebradine (85175-67-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 10h; under 3750.3 Torr; Ambient temperature;

DOI:10.1021/jm00167a033

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane (85175-76-4) → zatebradine (85175-67-3)

Guidance literature:

With sodium cyanoborohydride; In dichloromethane; acetic acid; acetonitrile;

upstream raw materials:

1-[7,8dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane

N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine

7,8-dimethoxy-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine

N-methylhomoveratrylamine

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