36770-74-8

Basic information

• Product Name: N-Methyl-N-(3-chloropropyl)-3,4-dimethoxyphenethylamine
• Synonyms: N-(3-CHLOROPROPYL)-3,4-DIMETHOXY-N-METHYLBENZENAMINE;N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine;N-Methyl-N-(3-chloropropyl)-3,4-dimethoxyphenethylamine;N-(3-Chloropropyl)-3,4-dimethoxy-N-methylbenzeneethanamine;N-(3-Chloropropyl)-N-methyl-3,4-dimethoxyphenethylamine;SR-45813;N-Methyl-N-(3-chloropropyl)-3,4-dimethoxybenzenethylamine;3-chloro-N-(3,4-diMethoxyphenethyl)-N-Methylpropan-1-aMine
• CAS NO: 36770-74-8
• Molecular Formula: C₁₄H₂₂ClNO₂
• Molecular Weight: 271.78
• EINECS: 253-198-8
• Mol File: 36770-74-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 361.8°Cat760mmHg
• Flash Point: 172.6°C
• Appearance: /
• Density: 1.066g/cm³
• Vapor Pressure: 2.02E-05mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 8.80±0.50(Predicted)
• CAS DataBase Reference: N-Methyl-N-(3-chloropropyl)-3,4-dimethoxyphenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-N-(3-chloropropyl)-3,4-dimethoxyphenethylamine(36770-74-8)
• EPA Substance Registry System: N-Methyl-N-(3-chloropropyl)-3,4-dimethoxyphenethylamine(36770-74-8)

Safety Data

• Hazardous Substances Data: 36770-74-8(Hazardous Substances Data)

Usage

Uses

N-(3-Chloropropyl)-3,4-dimethoxy-N-methylbenzeneethanamine (Verapamil EP Impurity D) is a reagent in the synthesis of Zatebradine, an anti-anginal agent.

InChI:InChI=1/C14H22ClNO2/c1-16(9-4-8-15)10-7-12-5-6-13(17-2)14(11-12)18-3/h5-6,11H,4,7-10H2,1-3H3

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 85175-54-8 3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)amino]-propanol 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 3490-06-0 N-methylhomoveratrylamine 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 57010-06-7 N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-N-methyl-m-dithiane-2-propylamine hydrobromide 
• 23313-68-0 verapamil hydrochloride 
• 52-53-9 Verapamil 
• 121345-73-1 4-{3-[N-methyl-N-(3,4-dimethoxy-β-phenethyl)amino]propyloxy}benzenesulphonylbenzene hydrochloride 
• 121346-61-0 1-Isobutyryl-1-[4-{3-[N methyl-N-(3,4-dimethoxy-β-phenethyl)amino]propyloxy}-benzenesulphonyl]cyclopropane 
• 114432-13-2 fantofarone 
• 1027036-42-5 1-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-piperidin-4-one oxime 
• 163981-89-3 1-<3-propyl>-4-aminopiperidine 
• 85175-67-3 zatebradine 
• 1026432-88-1 1-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-piperidin-4-one 
• 118646-17-6 3-<<2-(3,4-dimethoxyphenyl)ethyl>methylamino>propyl carbamimidothioate dihydrochloride 
• 121345-64-0 SR 33741 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF VERAPAMIL HYDROCHLORIDE

The present invention relates to a process for the preparation of 5-(3,4-dimethoxyphenylethyl) methyl-amino-2-(3,4-dimethoxyphenyl)-2-isopropyl valeronitrile, which is known as Verapamil. The present invention also relates to a process for improving the purity of verapamil and therefore of its hydrochloride represented as the compound of formula I, by efficient removal of the impurities formed, affording a product of purity greater than 99 %. The process of the present invention is simple, efficient, cost-effective and industrially feasible.

(Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them

3-(Phenylalkylaminoalkylozy)-heteroaryl compounds having heart rate lowering and/or anti-ischemic effects, methods for their preparation and pharmaceutical compositions containing them are described. The compounds correspond to the general formula I STR1 or to the general formula XXXI STR2 in which the substituents have the meanings given the specification.

Benzazepine derivatives, their pharmaceutical compositions and method of use

Compounds of the formula STR1 wherein A is --CH2 --CH2 --, --CH=CH--, --NH--CO--, --CH2 --CO-- or STR2 where R7 is alkyl of 1 to 3 carbon atoms, and B is methylene, carbonyl or thiocarbonyl, or A is --CO--CO--, --N=CH--, STR3 where R8 is hydrogen or alkyl of 1 to 3 carbon atoms substituted by a phenyl, methoxyphenyl or dimethoxyphenyl, and B is methylene; E is n-alkylene of 2 to 4 carbon atoms optionally substituted by an alkyl of 1 to 3 carbon atoms, 2-hydroxy-n-propylene, 2-hydroxy-n-butylene or 3-hydroxy-n-butylene; G is n-alkylene of 1 to 5 carbon atoms optionally substituted by an alkyl of 1 to 3 carbon atoms, wherein one methylene group of an n-alkylene of 2 to 5 carbon atoms can be replaced by a carbonyl group, with the proviso that B represents a methylene or carbonyl group, or methylene-n-hydroxy-alkylene of 1 to 4 carbon atoms, where the methylene group is attached to the nitrogen atom; and R1 to R5 are simple substituents of various types; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.