Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1,2-dihydro-1-((4-(4-nitrophenyl)-1-piperazinyl)methyl)-2-oxo-3H-indol-3-ylidene)hydrazide

Base Information

Chemical Name:Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1,2-dihydro-1-((4-(4-nitrophenyl)-1-piperazinyl)methyl)-2-oxo-3H-indol-3-ylidene)hydrazide
CAS No.:136603-21-9
Molecular Formula:C₄₂H₃₄N₈O₆
Molecular Weight:746.782
Hs Code.:
Mol file:136603-21-9.mol

Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1,2-dihydro-1-((4-(4-nitrophenyl)-1-piperazinyl)methyl)-2-oxo-3H-indol-3-ylidene)hydrazide

Synonyms:BRN 4900362;Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1,2-dihydro-1-((4-(4-nitrophenyl)-1-piperazinyl)methyl)-2-oxo-3H-indol-3-ylidene)hydrazide;136603-21-9;C42H34N8O6;C42-H34-N8-O6

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Chemical Property of Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1,2-dihydro-1-((4-(4-nitrophenyl)-1-piperazinyl)methyl)-2-oxo-3H-indol-3-ylidene)hydrazide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.4g/cm³
XLogP3:7.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:10
Exact Mass:746.26013083
Heavy Atom Count:56
Complexity:1350

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CN2C3=CC=CC=C3C(=C2O)N=NC(=O)COC4=CC=C(C=C4)C(=O)C5=C(N=C6C(=C5)C=CC=N6)C7=CC=CC=C7)C8=CC=C(C=C8)[N+](=O)[O-]

Technology Process of Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1,2-dihydro-1-((4-(4-nitrophenyl)-1-piperazinyl)methyl)-2-oxo-3H-indol-3-ylidene)hydrazide

There total 6 articles about Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1,2-dihydro-1-((4-(4-nitrophenyl)-1-piperazinyl)methyl)-2-oxo-3H-indol-3-ylidene)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7521-41-7
2-Aminonicotinaldehyde

: 136603-21-9
[4-(2-Phenyl-[1,8]naphthyridine-3-carbonyl)-phenoxy]-acetic acid [1-[4-(4-nitro-phenyl)-piperazin-1-ylmethyl]-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: conc. H₂SO₄, glac. AcOH

2: 65 percent / K₂CO₃ / acetone / 18 h / Heating

3: 60 percent / hydrazine hydrate / methanol / 8 h / Heating

4: 68 percent / glac. AcOH / methanol / 4 h / Heating

5: dimethylformamide; H₂O / 1) heating, 10 min, 2) r.t., overnight

With sulfuric acid; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 52046-71-6
1-(4-hydroxy-phenyl)-3-phenyl-propane-1,3-dione

: 136603-21-9
[4-(2-Phenyl-[1,8]naphthyridine-3-carbonyl)-phenoxy]-acetic acid [1-[4-(4-nitro-phenyl)-piperazin-1-ylmethyl]-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: conc. H₂SO₄, glac. AcOH

2: 65 percent / K₂CO₃ / acetone / 18 h / Heating

3: 60 percent / hydrazine hydrate / methanol / 8 h / Heating

4: 68 percent / glac. AcOH / methanol / 4 h / Heating

5: dimethylformamide; H₂O / 1) heating, 10 min, 2) r.t., overnight

With sulfuric acid; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 116625-85-5
3-p-Hydroxybenzoyl-2-phenyl-1,8-naphthyridine

: 136603-21-9
[4-(2-Phenyl-[1,8]naphthyridine-3-carbonyl)-phenoxy]-acetic acid [1-[4-(4-nitro-phenyl)-piperazin-1-ylmethyl]-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / K₂CO₃ / acetone / 18 h / Heating

2: 60 percent / hydrazine hydrate / methanol / 8 h / Heating

3: 68 percent / glac. AcOH / methanol / 4 h / Heating

4: dimethylformamide; H₂O / 1) heating, 10 min, 2) r.t., overnight

With potassium carbonate; hydrazine hydrate; acetic acid; In methanol; water; N,N-dimethyl-formamide; acetone;