Technology Process of Piperazine, 1-[2-bromo-10,11-dihydro-8-(1-methylethyl)dibenzo[b,f]thiepin-10-yl]-4-methyl-, methanesulfonate (1:1)
There total 8 articles about Piperazine, 1-[2-bromo-10,11-dihydro-8-(1-methylethyl)dibenzo[b,f]thiepin-10-yl]-4-methyl-, methanesulfonate (1:1) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / ethanol; H2O; tetrahydrofuran / 5 h / Heating
2: KOH / aq. ethanol / 6 h / Heating; from the crude nitrile INO 1500
3: 85 percent / polyphosphoric acid / 4.5 h / 150 °C
4: 96 percent / NaBH4 / ethanol / 1. 50 degC, 10 min 2. reflux, 30 min
5: 83 percent / HCl, CaCl2 / benzene / Ambient temperature; 1. saturation of solution with HCl gas, 4h 2. stand overnight
6: 86 percent / CHCl3 / 7 h / Heating
7: ethanol / Ambient temperature; neutralization of INO 1770 with INO 1800
With
hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; PPA; calcium chloride;
In
tetrahydrofuran; ethanol; chloroform; water; benzene;
DOI:10.1135/cccc19840086
- Guidance literature:
-
Multi-step reaction with 6 steps
1: KOH / aq. ethanol / 6 h / Heating; from the crude nitrile INO 1500
2: 85 percent / polyphosphoric acid / 4.5 h / 150 °C
3: 96 percent / NaBH4 / ethanol / 1. 50 degC, 10 min 2. reflux, 30 min
4: 83 percent / HCl, CaCl2 / benzene / Ambient temperature; 1. saturation of solution with HCl gas, 4h 2. stand overnight
5: 86 percent / CHCl3 / 7 h / Heating
6: ethanol / Ambient temperature; neutralization of INO 1770 with INO 1800
With
hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; PPA; calcium chloride;
In
ethanol; chloroform; benzene;
DOI:10.1135/cccc19840086
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / NaBH4 / ethanol / 1. 50 degC, 10 min 2. reflux, 30 min
2: 83 percent / HCl, CaCl2 / benzene / Ambient temperature; 1. saturation of solution with HCl gas, 4h 2. stand overnight
3: 86 percent / CHCl3 / 7 h / Heating
4: ethanol / Ambient temperature; neutralization of INO 1770 with INO 1800
With
hydrogenchloride; sodium tetrahydroborate; calcium chloride;
In
ethanol; chloroform; benzene;
DOI:10.1135/cccc19840086
