Synonyms:hydron;methanesulfonate
99% *data from raw suppliers
Methanesulfonic Acid *data from reagent suppliers
C
There total 168 articles about Hydron;methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 46.3%
Reference yield:
Reference yield:
The study presents the synthesis and characterization of novel, highly colored benzopentalenonaphthalenones derived from the intramolecular capture of a merocyanine moiety from diarylmethanol-substituted 2H-naphtho[1,2-b]pyrans under acidic conditions. These compounds exhibit interesting photochromic properties, changing color upon irradiation with ultraviolet light and reverting to colorless upon cessation of irradiation. The researchers also observed that the coloration was influenced by the electronic and steric properties of the substituents. Further, they explored the cascade process that leads to the formation of these compounds, involving initial intramolecular trapping of a cation and subsequent cyclization, tautomerization, and oxidation steps. The study provides insights into the design of new functional dyes with potential applications in areas such as dye-sensitized solar cells, photodynamic therapy, and sensor systems.
The study focuses on developing a novel palladium-catalyzed carbonylative Sonogashira reaction to synthesize α,β-ynones using aryl triazenes and alkynes as substrates. Aryl triazenes, which are easily prepared and stable, act as the starting materials that are transformed into aryl diazonium salts in the presence of methanesulfonic acid. The methanesulfonic acid plays multiple roles in the reaction: it assists in converting aryl triazenes to aryl diazonium salts, deprotonates terminal alkynes to facilitate the formation of a new Pd–C bond, and reacts with free amines to prevent unwanted side reactions. Palladium acetate (Pd(OAc)2) serves as the catalyst to initiate the oxidative addition step, forming an arylpalladium complex. Carbon monoxide coordinates and inserts into this complex to create an acylpalladium intermediate. Terminal alkynes then react with this intermediate, assisted by the methanesulfonic acid anion, to produce the desired α,β-ynones through reductive elimination. The study optimizes reaction conditions, including the use of various ligands and solvents, and demonstrates the tolerance of bromides, iodides, and hydroxyl groups under these conditions. The developed method provides a convenient and efficient route for synthesizing α,β-ynones, which are important compounds with special biological activities and serve as versatile intermediates for heterocycle and natural product syntheses.
The research focuses on the facile and efficient one-pot synthesis of 4β-arylaminopodophyllotoxins, which are potent DNA topoisomerase II inhibitors with potential as anticancer agents. The study reports a series of 4β-arylamino-4'-O-demethylepipodophyllotoxins and 4β-arylaminoepipodophyllotoxins synthesized with significant stereoselectivity and improved yields, using the methanesulphonic acid/sodium iodide reagent system. Key reactants include podophyllotoxin, methanesulphonic acid, sodium iodide, and various arylamines. The methodology involves the conversion of podophyllotoxin to 4'-O-demethylepipodophyllotoxin and subsequent reaction with arylamines in the presence of bases like BaCO3, K2CO3, or CsCO3 to yield the desired 4β-arylaminopodophyllotoxin derivatives. The experiments utilize different solvents to manipulate the selectivity of 4'-O-demethylation, with CHCl3 favoring 4'-O-demethylation and C-4 epimerization, while MeCN leading to C-4 epimerization without 4'-O-demethylation. Analytical techniques used to characterize the synthesized compounds include infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and mass spectrometry (MS). The synthesized compounds, such as NPF and W-68, exhibit improved topoisomerase II inhibition and cytotoxic activity compared to etoposide, a widely used anticancer drug.
The research focuses on the formal total synthesis of (-)-indolmycin, an antibiotic with antibacterial activity against Staphylococci, derived from an African strain of Streptomyces albus. The study aimed to prepare (+)-indolmycenic ester 4, a key intermediate for the synthesis of (-)-indolmycin, using a lipase-catalyzed kinetic resolution as a key step. The process involved the use of various chemicals, including epoxybutyrate derivatives, chlorohydrin, mesylate, and indole precursors. The researchers successfully synthesized (+)-indolmycenic ester 4 and formally accomplished the total synthesis of (-)-indolmycin, confirming its absolute configuration through the preparation of (+)-MTPA esters and NMR analysis. The study concluded that the lipase-catalyzed kinetic resolution was an effective method for achieving the synthesis with high optical purity.
The research details a novel one-pot preparation method for synthesizing tetrahydrobenzodipyran-4-ones and their subsequent conversion to dihydrobenzodipyrans, which are precocene analogues. The synthesis involves the sequential condensation of resorcinols with 3,3-dimethylacrylic acid and 1,3-dichloro-3-methylbutane in methanesulphonic acid, which acts as both solvent and catalyst. The study explores the synthesis of various substituted tetrahydrobenzodipyran-4-ones and their conversion to dihydrobenzodipyrans, with yields and reaction conditions optimized for different starting materials. The results provide a new synthetic route for these compounds, which have potential applications in insect control due to their insect anti-juvenile hormone (AJH) activity.
The research focuses on the synthesis and cytotoxic potency of novel tris(1-alkylindol-3-yl)methylium salts. The study demonstrates an easy substitution of indole rings in trisindolylmethanes for other indoles under the action of acids and discusses the mechanism of substitution. An environmentally safe method of oxidation of trisindolylmethanes with air oxygen in acidic conditions was developed to obtain trisindolylmethylium salts. The cytotoxicity of the novel compounds increased with the number of carbon atoms in the alkyl chains, with optimal potency observed for compounds with 3–5 carbon atoms. The most potent compounds killed human tumor cells at nanomolar-to-submicromolar concentrations, being significantly more potent than the prototype antibiotic turbomycin A. Key chemicals involved in the research include tris(indol-3-yl)methanes, tris(indol-3-yl)methylium salts, N-alkylindol-3-carboxaldehydes, N-substituted indoles, acetic acid, La(OTf)3, Dy(OTf)3, methanesulfonic acid, and various other reagents used for synthesis and biological testing. The study concludes that N-alkyl substituted tris(1-alkylindol-3-yl)methylium salts are promising candidates for further development as anticancer drugs.
The study presents a biomimetic oxidative coupling cyclization strategy for the functionalization of tetrahydrocarbolines (THCs) to rapidly construct complex isochromanoindolenine scaffolds. The reaction involves using iron(II) phthalocyanine (FePc) as a catalyst and 2,3-bishydroxybenzoic acid as a coupling partner, with tert-butyl hydroperoxide (TBHP) as the oxidant. Acetic acid and methanesulfonic acid (MsOH) are also used to enhance the reaction efficiency. The FePc catalyst is crucial for the conversion, facilitating the formation of a tert-butyloxy radical from TBHP, which abstracts a hydrogen atom from the THC substrate. The resulting radical species then reacts with an unstable ortho-quinone intermediate formed from the oxidation of 2,3-bishydroxybenzoic acid, ultimately yielding the desired isochromanoindolenine product through acid-mediated transformation. This method is scalable, operationally simple, and compatible with a wide range of functional groups, including electron-donating and electron-withdrawing groups, and can be applied to various THCs, such as tetrahydro-β-carbolines (THβCs) and tetrahydro-γ-carbolines (THγCs), to produce the corresponding products in moderate to excellent yields.
The research aims to develop a novel synthetic method for constructing complex organic molecules by forming C-C bonds through C-H activation, thereby reducing the need for multiple reactive functional groups in coupling reactions. The study focuses on synthesizing the core structure of teleocidin B4, a natural product with significant biological activity, using a series of C-C bond-forming steps that involve C-H bond functionalization. Key chemicals used include tert-butyl aniline derivatives, Pd(II) salts (specifically PdCl2) for cyclometalation, NaOAc as a base, vinyl boronic acids for transmetalation, and methanesulfonic acid for Friedel-Crafts reactions. The researchers successfully synthesized the teleocidin B4 core through a sequence of reactions involving alkenylation, Friedel-Crafts hydroarylation, diastereoselective carbonylation, and intramolecular alkenylation coupling. The final product was obtained in 57% yield after optimization of reaction conditions. The study concludes that C-H bond activation provides a powerful and efficient approach to synthesizing complex natural products, potentially inspiring new chemical transformations and synthetic strategies in organic chemistry.
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