N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(((methylamino)sulfonyl)amino)benzamide

Base Information

Chemical Name:N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(((methylamino)sulfonyl)amino)benzamide
CAS No.:90763-31-8
Molecular Formula:C16H26N4O4S
Molecular Weight:370.467
Hs Code.:
DSSTox Substance ID:DTXSID60920179
ChEMBL ID:CHEMBL14597

Synonyms:BRN 5623696;90763-31-8;N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(((methylamino)sulfonyl)amino)benzamide;Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(((methylamino)sulfonyl)amino)-;CHEMBL14597;DTXSID60920179;LS-26833;N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-[(methylsulfamoyl)amino]benzene-1-carboximidic acid

Suppliers and Price of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(((methylamino)sulfonyl)amino)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(((methylamino)sulfonyl)amino)benzamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.249g/cm³
XLogP3:0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:370.16747650
Heavy Atom Count:25
Complexity:537

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)NS(=O)(=O)NC)OC

Technology Process of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(((methylamino)sulfonyl)amino)benzamide

There total 4 articles about N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(((methylamino)sulfonyl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 10438-96-7
N-methylsulfamoyl chloride

: 68255-81-2
N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-aminobenzamide

: 90763-31-8
C₁₆H₂₆N₄O₄S

Guidance literature:: With triethylamine; In dichloromethane; for 0.25h;
DOI:10.1021/jm00375a009

Reference yield:

: 40751-89-1
2-methoxy-5-nitrobenzoic acid

: 90763-31-8
C₁₆H₂₆N₄O₄S

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 1 h / Heating

2: Et₃N / CH₂Cl₂ / 0.25 h / Ambient temperature

3: 35 percent / Sn, HCl aq. / 4 h / 50 °C

4: 57 percent / Et₃N / CH₂Cl₂ / 0.25 h

With hydrogenchloride; tin; thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm00375a009

Reference yield:

: 90763-46-5
2-methoxy-5-nitrobenzoyl chloride

: 90763-31-8
C₁₆H₂₆N₄O₄S

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.25 h / Ambient temperature

2: 35 percent / Sn, HCl aq. / 4 h / 50 °C

3: 57 percent / Et₃N / CH₂Cl₂ / 0.25 h

With hydrogenchloride; tin; triethylamine; In dichloromethane;
DOI:10.1021/jm00375a009