10438-96-7

Basic information

• Product Name: METHYLSULFAMOYL CHLORIDE
• Synonyms: METHYLSULFAMOYL CHLORIDE;Methylaminosulfonyl chloride;N-Methylaminosulfonyl chloride;N-Methylsulfamoyl chloride;N-methyl-Sulfamoyl chloride;(MethylsulfaMoyl)chloranuide
• CAS NO: 10438-96-7
• Molecular Formula: CH₄ClNO₂S
• Molecular Weight: 129.56596
• Mol File: 10438-96-7.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 188.9±23.0℃ (760 Torr)
• Flash Point: 68.0±22.6℃
• Appearance: /
• Density: 1.501±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.585mmHg at 25°C
• Refractive Index: 1.468
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.91±0.40(Predicted)
• CAS DataBase Reference: METHYLSULFAMOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYLSULFAMOYL CHLORIDE(10438-96-7)
• EPA Substance Registry System: METHYLSULFAMOYL CHLORIDE(10438-96-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 10438-96-7(Hazardous Substances Data)

Usage

Uses

Methylsulfamoyl Chloride is used in preparation of substituted MEK inhibitors and therapeutic uses thereof.

InChI:InChI=1/CH4ClNO2S/c1-3-6(2,4)5/h3H,1H3

Upstream product

• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 
• 4112-03-2 N-methylsulfamic acid 

Downstream Products

• 22504-72-9 N,N'-dimethylsulfamide 
• 26153-46-8 N-Methyl-amidosulfonsaeure-cyclohexylester 
• 102276-47-1 N-Methyl-N'-<(4-chlor-2-benzoyl)phenyl>-sulfamid 
• 136166-39-7 Methylsulfamic acid 3-phenoxy-1,2-propanediyl ester 
• 136167-45-8 methylsulfamic acid 2-[[(methylamino)sulfonyl]oxy]-3-[2-(phenylmethoxy)phenoxy]propyl ester 
• 115-77-5 Pentaerythritol 
• 150999-51-2 methylsulfamic acid 2-(4-chlorophenoxy)-1,3-propanediyl ester 
• 26119-97-1 methylsulfamic acid phenyl ester 
• 136166-82-0 Methylsulfamic acid 1-chloro-3-(2-methoxyphenoxy)-2-propyl ester 
• 104637-66-3 Benzoesaeure-<2-(methylaminosulfonyl)-2-(phenylmethyl)>hydrazid 
• 104637-69-6 Essigsaeure-<2-(methylaminosulfonyl)-2-(phenylmethyl)>hydrazid 
• 102276-33-5 N-Methyl-1-phenyl-2-(phenylmethylen)-hydrazinsulfonamid 
• 102276-31-3 N-Methyl-2-(4-nitrophenyl)-hydrazinsulfonamid 
• 102276-30-2 N-Methyl-2-phenyl-hydrazinsulfonamid 

Relevant articles and documents

Regioselective C(sp3)-H alkylation of a fructopyranose derivative by 1,6-HAT

Regioselective C(sp3)-H alkylation of a fructopyranose derivative using electron-deficient alkenes as alkylation reagents was achieved. The reaction proceededvia1,6-hydrogen atom transfer under photoredox iridium catalysis. Several functional g

Catalytic Sulfamoylation of Alcohols with Activated Aryl Sulfamates

We report a new catalytic method for alcohol sulfamoylation that deploys electron-deficient aryl sulfamates as activated group transfer reagents. The reaction utilizes the simple organic base N-methylimidazole, proceeds under mild conditions, and provides

BROMODOMAIN-INHIBITING COMPOUNDS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING OR TREATING A CANCER

Provided is a novel compound having bromodomain and extra terminal domain (BET) protein inhibiting activities, and a pharmaceutical composition comprising the same which can be useful for prevention or treatment of precancerous transformation or cancer.