4-(2-FURYL)-2,4-DIOXOBUTANOIC ACID

Base Information

• Chemical Name: 4-(2-FURYL)-2,4-DIOXOBUTANOIC ACID
• CAS No.: 105356-51-2
• Molecular Formula: C₈H₆O₅
• Molecular Weight: 182.133
• Hs Code.: 2932190090
• Mol file: 105356-51-2.mol

Synonyms:4-(2-FURYL)-2,4-DIOXOBUTANOIC ACID;4-(Fur-2-yl)-2,4-dioxobutanoic acid

Chemical Property of 4-(2-FURYL)-2,4-DIOXOBUTANOIC ACID

Chemical Property:

• Vapor Pressure: 0.000591mmHg at 25°C
• Boiling Point: 362.1°Cat760mmHg
• PKA: 2.08±0.54(Predicted)
• Flash Point: 172.8°C
• PSA: 84.58000
• Density: 1.417g/cm³
• LogP: 0.50610

Purity/Quality:

98% ^*data from raw suppliers

4-(Fur-2-yl)-2,4-dioxobutanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-FURYL)-2,4-DIOXOBUTANOIC ACID

There total 3 articles about 4-(2-FURYL)-2,4-DIOXOBUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) → 4-(2-furyl)-2,4-dioxobutanoic acid (105356-51-2)

Guidance literature:

1-(2-furyl)-1-ethanone; dialkyl oxalate (R=Me or Et); With sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; methanol; for 4h;

DOI:10.1016/j.bmcl.2004.07.028

Reference yield:

ethyl 4-(furan-2-yl)-2,4-dioxobutyrate (36983-35-4) → 4-(2-furyl)-2,4-dioxobutanoic acid (105356-51-2)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1021/jm0342109

Reference yield:

1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) → 4-(2-furyl)-2,4-dioxobutanoic acid (105356-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / tetrahydrofuran / 20 °C

2: NaOH / methanol

With sodium hydroxide; sodium ethanolate; In tetrahydrofuran; methanol;

DOI:10.1021/jm0342109

upstream raw materials:

ethyl 4-(furan-2-yl)-2,4-dioxobutyrate

1-(2-furyl)-1-ethanone

Refernces

• 1、 Tumey, L. Nathan,Huck, Bayard,Gleason, Elizabeth,Wang, Jianmin,Silver, Daniel,Brunden, Kurt,Boozer, Sherry,Rundlett, Stephen,Sherf, Bruce,Murphy, Steven,Bailey, Andrew,Dent, Tom,Leventhal, Christina,Harrington, John,Bennani, Youssef L.. "The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors". . p. 4915 - 4918. Retrieved 2007/10/03.