N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-4-(dimethylamino)-2-methoxybenzamide

Base Information

Chemical Name:N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-4-(dimethylamino)-2-methoxybenzamide
CAS No.:112885-55-9
Molecular Formula:C22H28 Cl N3 O3
Molecular Weight:417.93
Hs Code.:
Mol file:112885-55-9.mol

Synonyms:N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-4-(dimethylamino)-2-methoxybenzamide

Suppliers and Price of N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-4-(dimethylamino)-2-methoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N-((4-BENZYL-2-MORPHOLINYL)METHYL)-5-CHLORO-4-(DIMETHYLAMINO)-2-METHOXYBENZAMIDE 95.00%
5MG
$ 497.62

Total 1 raw suppliers

Chemical Property of N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-4-(dimethylamino)-2-methoxybenzamide

Chemical Property:

Vapor Pressure:2.42E-11mmHg at 25°C
Boiling Point:530.6°Cat760mmHg
PKA:13.51±0.46(Predicted)
Flash Point:274.7°C
Density:1.205g/cm³

Purity/Quality:: N-((4-BENZYL-2-MORPHOLINYL)METHYL)-5-CHLORO-4-(DIMETHYLAMINO)-2-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-4-(dimethylamino)-2-methoxybenzamide

There total 8 articles about N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-4-(dimethylamino)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 61695-09-8
5-chloro-4-dimethylamino-2-methoxybenzoic acid

: 110859-47-7,140646-11-3
(4-benzylmorpholin-2-yl)methanamine

: 112885-55-9
N-<(4-benzyl-2-morpholinyl)methyl>-5-chloro-4-(dimethylamino)-2-methoxybenzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/jm00167a020

Reference yield:

: 147767-51-9,126645-52-1
4-benzyl-2-cyanomorpholine

: 112885-55-9
N-<(4-benzyl-2-morpholinyl)methyl>-5-chloro-4-(dimethylamino)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) H₂, acetic acid / 1.) Raney nickel / 1.) 95 percent EtOH, RT, 2.) CHCl₃, RT, 2 h

2: 100 percent / 10percent HCl / 4 h / Heating

3: 88 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel; In dichloromethane;
DOI:10.1021/jm00167a020

Reference yield:

: 104-63-2
N-Benzylethanolamine

: 112885-55-9
N-<(4-benzyl-2-morpholinyl)methyl>-5-chloro-4-(dimethylamino)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 3 h / 80 °C

2: concd. H₂SO₄ / 1 h / 150 °C

3: 88 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jm00167a020