1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid
CAS No.:126581-82-6
Molecular Formula:C₁₁H₁₁BrN₂O₃
Molecular Weight:299.124
Hs Code.:2933990090
DSSTox Substance ID:DTXSID00385945
ChEMBL ID:CHEMBL1467274
Mol file:126581-82-6.mol

Synonyms:126581-82-6;1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid;1-(5-bromopyridine-3-carbonyl)pyrrolidine-2-carboxylic acid;1-(5-Bromonicotinoyl)pyrrolidine-2-carboxylic acid;MLS000107027;(5-Bromonicotinoyl)proline;CBKinase1_000754;CBKinase1_013154;Cambridge id 5491946;Oprea1_407484;Oprea1_622062;CHEMBL1467274;DTXSID00385945;HMS1675G03;HMS2494P16;STK525674;AKOS000549025;AKOS016050295;1-(5-Bromopyridine-3-carbonyl)proline;WAY-297759;SMR000111401;1-[(5-bromopyridin-3-yl)carbonyl]proline;CS-0318640;AB00086988-01;1-(5-Bromonicotinoyl)pyrrolidine-2-carboxylicacid;SR-01000406399;J-005402;SR-01000406399-1;BRD-A04307069-001-01-8;1-(5-bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid, AldrichCPR

Suppliers and Price of 1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid
1g
$ 378.00

Crysdot
1-(5-Bromonicotinoyl)pyrrolidine-2-carboxylicacid 97%
5g
$ 701.00

American Custom Chemicals Corporation
1-(5-BROMO-PYRIDINE-3-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID 95.00%
1G
$ 672.00

AK Scientific
1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylicacid
1g
$ 560.00

Total 3 raw suppliers

Chemical Property of 1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid

Chemical Property:

Vapor Pressure:7.74E-11mmHg at 25°C
Melting Point:157-158 °C
Boiling Point:500.5°Cat760mmHg
PKA:3.31±0.20(Predicted)
Flash Point:256.5°C
PSA：70.50000
Density:g/cm³
LogP:1.47120
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:297.99530
Heavy Atom Count:17
Complexity:324

Purity/Quality:

98%min ^*data from raw suppliers

1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(N(C1)C(=O)C2=CC(=CN=C2)Br)C(=O)O

Technology Process of 1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid

There total 3 articles about 1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 112193-42-7
(5-bromo-3-pyridyl)carbonyl azide

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 126581-82-6
1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; at 20 ℃; for 0.5h; pH 9-9.5;
DOI:10.1007/BF00764700

Reference yield:

: 20986-40-7
ethyl 5-bromo-3-pyridinecarboxylate

: 126581-82-6
1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / hydrazine hydrate / 1 h / Heating

2: 88 percent / conc. HCl, NaNO₂ / H₂O / 0.5 h / 0 °C

3: 59 percent / 1 N NaOH / 0.5 h / 20 °C / pH 9-9.5

With hydrogenchloride; sodium hydroxide; hydrazine hydrate; sodium nitrite; In water;
DOI:10.1007/BF00764700

Reference yield:

: 112193-41-6
5-bromonicotinic acid hydrazide

: 126581-82-6
1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / conc. HCl, NaNO₂ / H₂O / 0.5 h / 0 °C

2: 59 percent / 1 N NaOH / 0.5 h / 20 °C / pH 9-9.5

With hydrogenchloride; sodium hydroxide; sodium nitrite; In water;
DOI:10.1007/BF00764700