112193-41-6

Basic information

• Product Name: 5-BROMOPYRIDINE-3-CARBOHYDRAZIDE
• Synonyms: BUTTPARK 98\04-61;5-BROMONICOTINOHYDRAZIDE;5-BROMOPYRIDINE-3-CARBOHYDRAZIDE;AKOS BBS-00000359;5-BROMOPYRIDINE-3-CARBOXYLIC ACID HYDRAZIDE;3-Pyridinecarboxylicacid, 5-bromo-, hydrazide;5-bromo-3-pyridinecarbohydrazide;5-Bromo-nicotinic acid hydrazide
• CAS NO: 112193-41-6
• Molecular Formula: C₆H₆BrN₃O
• Molecular Weight: 216.04
• Mol File: 112193-41-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 204-205
• Appearance: /
• Density: 1.709 g/cm³
• Refractive Index: 1.623
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10?+-.0.10(Predicted)
• CAS DataBase Reference: 5-BROMOPYRIDINE-3-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMOPYRIDINE-3-CARBOHYDRAZIDE(112193-41-6)
• EPA Substance Registry System: 5-BROMOPYRIDINE-3-CARBOHYDRAZIDE(112193-41-6)

Safety Data

• Hazard Codes: Xi
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• HazardClass: IRRITANT
• Hazardous Substances Data: 112193-41-6(Hazardous Substances Data)

Usage

General Description

5-Bromopyridine-3-carbohydrazide is a chemical compound with the molecular formula C5H5BrN3O. It belongs to the group of organic compounds known as pyridine carbazides. It's an important reactant used in the synthesis of various organic compounds, which includes pharmaceutical drugs and agrochemicals. Its physical properties are characterized by a heavy, yellow-brown crystalline powder that appears white in its pure form. The toxicological properties of this compound have not been fully investigated, hence, it should be handled with caution. It is primarily used in scientific research and not widely available commercially, with primary use in laboratories.

InChI:InChI=1/C6H6BrN3O/c7-5-1-4(2-9-3-5)6(11)10-8/h1-3H,8H2,(H,10,11)

Upstream product

• 98555-51-2 5-Bromo-pyridine-2,3-dicarboxylic acid 
• 20986-40-7 ethyl 5-bromo-3-pyridinecarboxylate 
• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 39620-02-5 5-bromonicotinoyl chloride 

Downstream Products

• 113118-81-3 5-bromopyridine-3-carbaldehyde 
• 118420-37-4 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-bromo-pyridin-3-yl)-acrylamide 
• 1464794-49-7 (E)-2-(5-bromopyridin-3-yl)-5-(3,4,5-trimethoxystyryl)-1,3,4-oxadiazole 
• 1201594-83-3 4-[5-(5-bromopyridin-3-yl)-1,3,4-thiadiazol-2-yl]benzonitrile 
• 126581-82-6 1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid 
• 1272355-45-9 5-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine 
• 1039851-68-7 5-(5-bromopyridin-3-yl)-1,3,4-oxadiazol-2-amine 
• 1198081-97-8 (E)-5-bromonicotinic acid [1-(4-chlorophenyl)methylidene]hydrazide 

Relevant articles and documents

TRIAZOLE AGONISTS OF THE APJ RECEPTOR

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures where the definitions of the variables are provided herein.

SUBSTITUTED PYRIDINE COMPOUNDS AS CRAC MODULATORS

The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release- activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I)and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.

Synthesis and pharmacological activity of amino acid derivatives of nicotinic acid

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