1,4,4-Trimethylpiperidine

Base Information

• Chemical Name: 1,4,4-Trimethylpiperidine
• CAS No.: 1003-84-5
• Molecular Formula: C8H17N
• Molecular Weight: 127.2273
• Mol file: 1003-84-5.mol

Synonyms:

Chemical Property of 1,4,4-Trimethylpiperidine

Chemical Property:

• Vapor Pressure: 7.3mmHg at 25°C
• Boiling Point: 136.7°C at 760 mmHg
• Flash Point: 29.9°C
• Density: 0.815g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,4-Trimethylpiperidine

There total 5 articles about 1,4,4-Trimethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,3,3-trimethylglutarimide (25115-67-7) → 1,4,4-trimethylpiperidine (1003-84-5)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In benzene; for 6h; Heating;

Reference yield:

3,3-Dimethylglutaric acid (4839-46-7) → 1,4,4-trimethylpiperidine (1003-84-5)

Guidance literature:

Multi-step reaction with 2 steps

2: lithium alanate; diethyl ether

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/ja01576a056

Reference yield:

3,3-dimethyl glutarimide (1123-40-6) → 1,4,4-trimethylpiperidine (1003-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / dimethylformamide

2: 85 percent / sodium bis-(methoxyethoxy)aluminum hydride / benzene / 6 h / Heating

With sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; In N,N-dimethyl-formamide; benzene;

upstream raw materials:

N,3,3-trimethylglutarimide

3,3-dimethyl glutarimide

3,3-dimethylglutaric anhydride

3,3-Dimethylglutaric acid

Downstream raw materials:

1,4,4-Trimethyl-1,4,5,6-tetrahydropyridin

1-amino-1,4,4-trimethylpiperidinium mesitylenesulfonate

Refernces

• 1、 Posvic, Harvey,Meireles, Jorge C. de. "The Thermolysis of Heterocyclic Aminimines". . p. 1241 - 1243. Retrieved 2007/10/02.