3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-4-oxo-1-phenyl-7-(1-p iperazinyl)-

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-4-oxo-1-phenyl-7-(1-p iperazinyl)-
CAS No.:98106-13-9
Molecular Formula:C20H18 F N3 O3
Molecular Weight:0
Hs Code.:
Mol file:98106-13-9.mol

Synonyms:3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-4-oxo-1-phenyl-7-(1-p iperazinyl)-

Suppliers and Price of 3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-4-oxo-1-phenyl-7-(1-p iperazinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-4-oxo-1-phenyl-7-(1-p iperazinyl)-

Chemical Property:

Vapor Pressure:1.18E-15mmHg at 25°C
Boiling Point:608.4°Cat760mmHg
Flash Point:321.7°C
PSA：74.57000
Density:1.391g/cm³
LogP:2.63140

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-4-oxo-1-phenyl-7-(1-p iperazinyl)-

There total 12 articles about 3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-4-oxo-1-phenyl-7-(1-p iperazinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 110-85-0
piperazine

: 836619-84-2
6,7-Difluoro-1,4-dihydro-4-oxo-1-phenyl-3-quinolinecarboxylic acid

: 98106-13-9
1-phenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid

Guidance literature:: In acetonitrile;
DOI:10.1021/jm00015a021

Reference yield:

: 446-17-3
2,4,5-trifluorobenzoic acid

: 98106-13-9
1-phenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) (COCl)2, 2.) C₃H₇MgCl / 1.) CH₂Cl₂, DMF, 2.) THF

2: 1.) Ac₂O / 2.) Et₂O

3: NaH / tetrahydrofuran

4: 6 M HCl

5: 85 percent / acetonitrile

With hydrogenchloride; oxalyl dichloride; C₃H₇MgCl; acetic anhydride; sodium hydride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00015a021

Reference yield:

: 98349-24-7
ethyl 2,4,5-trifluorobenzoylacetate

: 98106-13-9
1-phenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Ac₂O / 2.) Et₂O

2: NaH / tetrahydrofuran

3: 6 M HCl

4: 85 percent / acetonitrile

With hydrogenchloride; acetic anhydride; sodium hydride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00015a021