ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
• CAS No.: 10350-10-4
• Molecular Formula: C9H11 N O4
• Molecular Weight: 197.19
• Hs Code.: 2933399090
• Mol file: 10350-10-4.mol

Synonyms:Nicotinicacid, 1,2-dihydro-4-hydroxy-6-methyl-2-oxo-, ethyl ester (7CI); Nicotinic acid,2,4-dihydroxy-6-methyl-, ethyl ester (6CI); Ethyl1,2-dihydro-4-hydroxy-6-methyl-2-oxo-3-pyridinecarboxylate; Ethyl4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate; NSC 109231

Chemical Property of ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 216-222°C
• Boiling Point: 396.5°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 193.6°C
• PSA: 79.39000
• Density: 1.292g/cm³
• LogP: 0.56560
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 2,4-Dihydroxy-6-methylnicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2,4-Dihydroxy-6-methylnicotinate, is a building block used for various chemical compounds. It is used for the synthesis of analogs of Lucanthone, having antitumor and bactericidal properties.

Technology Process of ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE

There total 6 articles about ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.85%

ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3) + diethyl malonate (105-53-3) → ethyl 2,4-dihydroxy-6-methylnicotinate (10350-10-4,70254-52-3,70254-53-4)

Guidance literature:

With sodium ethanolate; In ethanol; at 80 - 90 ℃; for 24h; Temperature;

Reference yield: 77.0%

ethanol (64-17-5) + 4-hydroxy-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (846557-80-0) → ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate (10350-10-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In toluene; at 50 ℃; for 16h; Green chemistry;

Reference yield: 76.0%

ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3) + diethyl malonate (105-53-3) → ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate (10350-10-4)

Guidance literature:

With sodium ethanolate; In ethanol; at 140 - 160 ℃; for 17h;

upstream raw materials:

ethyl aminocrotonate

diethyl malonate

4-hydroxy-6-methyl-2-pyridone

ethanol

Downstream raw materials:

2,4-dihydroxy-6-methyl-5-(4-nitro-phenylsulfanyl)-nicotinic acid ethyl ester

2,4-dihydroxy-6-methylpyridine

2,4-dichloro-6-methyl-nicotinoyl chloride

ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate

Refernces

• 1、 -. "A 2, 4 - dihydroxy - 6 - methyl-nicotinic acid ethyl ester preparation method (by machine translation)". Paragraph 0021; 0022. . Retrieved 2017/02/09.