4,6-Dichloro-5-ethylpyrimidin-2-amine

Base Information

• Chemical Name: 4,6-Dichloro-5-ethylpyrimidin-2-amine
• CAS No.: 6343-68-6
• Molecular Formula: C₆H₇Cl₂N₃
• Molecular Weight: 192.048
• Hs Code.: 2933599090
• NSC Number: 49720
• DSSTox Substance ID: DTXSID70287220
• Wikidata: Q82023184
• Mol file: 6343-68-6.mol

Synonyms:4,6-dichloro-5-ethylpyrimidin-2-amine;6343-68-6;2-AMINO-4,6-DICHLORO-5-ETHYLPYRIMIDINE;NSC 49720;NSC49720;SCHEMBL12495474;DTXSID70287220;AMY14114;MFCD11110662;NSC-49720;AKOS006309826;DS-6606;SB57473;CS-0028717

Chemical Property of 4,6-Dichloro-5-ethylpyrimidin-2-amine

Chemical Property:

• Vapor Pressure: 4.54E-05mmHg at 25°C
• Boiling Point: 349.9oC at 760 mmHg
• PKA: 0.50±0.10(Predicted)
• Flash Point: 165.4oC
• PSA: 51.80000
• Density: 1.423g/cm3
• LogP: 2.50920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 191.0017026
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

97% ^*data from raw suppliers

4,6-Dichloro-5-ethylpyrimidin-2-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(N=C(N=C1Cl)N)Cl

Technology Process of 4,6-Dichloro-5-ethylpyrimidin-2-amine

There total 6 articles about 4,6-Dichloro-5-ethylpyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 4,6-dichloro-5-ethylpyrimidin-2-amine (6343-68-6)

Guidance literature:

Reference yield:

4,6-dichloro-5-ethyl-2-{[(dimethylamino)methylene]amino}pyrimidine (1395342-97-8) → 4,6-dichloro-5-ethylpyrimidin-2-amine (6343-68-6)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 50 ℃; for 2h;

DOI:10.1007/s00044-014-1018-9

Reference yield:

ethyl diethyl malonate (133-13-1) → 4,6-dichloro-5-ethylpyrimidin-2-amine (6343-68-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium / ethanol / 4 h / 20 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere; Reflux

2.1: chloroform / 4 h / Inert atmosphere; Reflux

3.1: hydrogenchloride / water; ethanol / 2 h / 50 °C

With hydrogenchloride; sodium; In ethanol; chloroform; water;

DOI:10.1007/s00044-014-1018-9

upstream raw materials:

trichlorophosphate

4,6-dichloro-5-ethyl-2-{[(dimethylamino)methylene]amino}pyrimidine

ethyl diethyl malonate

2-amino-5-ethylpyrimidine-4,6-diol

Downstream raw materials:

5-ethyl-4,6-dimethoxy-pyrimidin-2-ylamine

2-Amino-5-ethylpyrimidin

6-chloro-5-ethylpyrimidine-2,4-diamine

N-acetyl-sulfanilic acid-(5-ethyl-4,6-dimethoxy-pyrimidin-2-ylamide)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 6343-68-6 2-Amino-4,6-dichloro-5-ethylpyrimidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send