Bis(p-acetoxyphenyl) sulfone

Base Information

• Chemical Name: Bis(p-acetoxyphenyl) sulfone
• CAS No.: 5456-51-9
• Molecular Formula: C16H14O6S
• Molecular Weight: 334.35
• NSC Number: 689434,21515
• DSSTox Substance ID: DTXSID00281397
• Nikkaji Number: J31.787J
• Wikidata: Q82015313
• ChEMBL ID: CHEMBL219778
• Mol file: 5456-51-9.mol

Synonyms:5456-51-9;NSC689434;NSC21515;MLS001033512;4,4'-Diacetoxydiphenylsulfone;CHEMBL219778;SCHEMBL9343618;DTXSID00281397;UVSACKAENHNCEZ-UHFFFAOYSA-N;HMS1730E04;HMS2729E04;Sulfonyldi-4,1-phenylene diacetate;NSC-21515;Sulfonyldi(4,1-phenylene) diacetate;Sulfonylbis(4,1-phenylene) diacetate;AKOS001094737;NSC-689434;80-09-1, Ac;SMR000385623;[4-(4-acetoxyphenyl)sulfonylphenyl] acetate;Z30863781;acetic acid 4-(4-acetoxy-benzenesulfonyl)-phenyl ester

Chemical Property of Bis(p-acetoxyphenyl) sulfone

Chemical Property:

• Vapor Pressure: 5.14E-10mmHg at 25°C
• Boiling Point: 497°C at 760 mmHg
• Flash Point: 254.4°C
• PSA: 95.12000
• Density: 1.321g/cm³
• LogP: 3.45080
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 334.05110934
• Heavy Atom Count: 23
• Complexity: 477

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)OC(=O)C

Technology Process of Bis(p-acetoxyphenyl) sulfone

There total 10 articles about Bis(p-acetoxyphenyl) sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4,4'-sulfonediphenol (80-09-1,59790-00-0) + acetyl chloride (75-36-5) → 4,4'-diacetoxydiphenylsulfone (5456-51-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1128/aac.41.2.385

Reference yield:

bis(4-hydroxyphenyl) sulfoxide (1774-34-1) → 4,4'-diacetoxydiphenylsulfone (5456-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Erwaermen auf dem Dampfbad

2: CrO₃; water; acetic acid

With chromium(VI) oxide; water; acetic acid;

Reference yield:

phenol (108-95-2,27073-41-2) → 4,4'-diacetoxydiphenylsulfone (5456-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: fuming sulfuric acid / 180 - 190 °C

2: glacial acetic acid

With sulfuric acid; acetic acid;

upstream raw materials:

bis-(4-acetoxy-phenyl)-sulfoxide

4,4'-sulfonediphenol

acetic anhydride

acetyl chloride

Downstream raw materials:

3,3'-diacetyl-4,4'-dihydroxydiphenylsulfone

dapsone

acedapsone

4,4'-sulfonediphenol

Refernces