N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2,6-difluorobenzamide

Base Information

Chemical Name:N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2,6-difluorobenzamide
CAS No.:6179-32-4
Molecular Formula:C15H8ClF2N3OS
Molecular Weight:204.225
Hs Code.:
DSSTox Substance ID:DTXSID90411368

Synonyms:6179-32-4;N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2,6-difluorobenzamide;392245-08-8;N-(5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl)-2,6-difluorobenzamide;Oprea1_006217;DTXSID90411368;AKOS024575664;FT-0769249;AB00667498-01;F0326-1211

Suppliers and Price of N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2,6-difluorobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2,6-difluorobenzamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.53g/cm³
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:351.0044671
Heavy Atom Count:23
Complexity:424

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=NN=C(S2)NC(=O)C3=C(C=CC=C3F)F)Cl

Technology Process of N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2,6-difluorobenzamide

There total 1 articles about N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24698-77-9
ethyl Chroman-2-carboxylate

: 6179-32-4
ethyl 4H-chromene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - -30 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

2.1: dihydrogen peroxide / tetrahydrofuran; hexane / 3 h / 0 °C / Inert atmosphere

With n-butyllithium; dihydrogen peroxide; diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1002/anie.201301341

Reference yield:

: 6179-32-4
ethyl 4H-chromene-2-carboxylate

: N-phenylchroman-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; methanol / 5 h / 50 °C

2: caesium carbonate; hydrogen; C₆₃H₇₈IrNOP⁽²⁺⁾*C₃₂H₁₂BF₂₄^(1-) / methanol / 12 h / 60 °C / 4560.31 Torr / Autoclave

3: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h

With dmap; C₆₃H₇₈IrNOP⁽²⁺⁾*C₃₂H₁₂BF₂₄^(1-); hydrogen; caesium carbonate; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1002/anie.201301341