[4-(4-Methylbenzyl)piperazin-1-yl](phenyl)methanone

Base Information

Chemical Name:[4-(4-Methylbenzyl)piperazin-1-yl](phenyl)methanone
CAS No.:5834-14-0
Molecular Formula:C19H22N2O
Molecular Weight:294.3908
Hs Code.:
DSSTox Substance ID:DTXSID80973905
Wikidata:Q82958017

Synonyms:[4-(4-methylbenzyl)piperazin-1-yl](phenyl)methanone;Cambridge id 5834140;Oprea1_334590;Oprea1_848947;AG-690/12781997;DTXSID80973905;[4-[(4-methylphenyl)methyl]piperazin-1-yl]-phenylmethanone;STK137693;AKOS003273205;CCG-318148;AB00098577-01;SR-01000221417;SR-01000221417-1;[4-(4-METHYLBENZYL)PIPERAZINO](PHENYL)METHANONE;1-[(4-methylphenyl)methyl]-4-(phenylcarbonyl)piperazine;{4-[(4-Methylphenyl)methyl]piperazin-1-yl}(phenyl)methanone

Suppliers and Price of [4-(4-Methylbenzyl)piperazin-1-yl](phenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-(4-Methyl-thiophen-2-yl)-acrylicacid 95%
5g
$ 1200.00

Matrix Scientific
3-(4-Methyl-thiophen-2-yl)-acrylicacid 95%
1g
$ 640.00

A1 Biochem Labs
3-(4-Methyl-thiophen-2-yl)-acrylicacid 95%
1 g
$ 400.00

Total 3 raw suppliers

Chemical Property of [4-(4-Methylbenzyl)piperazin-1-yl](phenyl)methanone

Chemical Property:

Vapor Pressure:5.37E-08mmHg at 25°C
Melting Point:137 - 138 °C
Boiling Point:441.6°Cat760mmHg
Flash Point:186.3°C
PSA：65.54000
Density:1.131g/cm³
LogP:2.15430
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:294.173213330
Heavy Atom Count:22
Complexity:348

Purity/Quality:: 3-(4-Methyl-thiophen-2-yl)-acrylicacid 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)CN2CCN(CC2)C(=O)C3=CC=CC=C3

Technology Process of [4-(4-Methylbenzyl)piperazin-1-yl](phenyl)methanone

There total 2 articles about [4-(4-Methylbenzyl)piperazin-1-yl](phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 6030-36-0
4-methylthiophene-2-carbaldehyde

: 141-82-2
malonic acid

: 5834-14-0
3-(4-methyl-thiophen-2-yl)-acrylic acid

Guidance literature:: With piperidine; pyridine; at 115 ℃;
DOI:10.1016/j.ejmech.2014.08.042

Reference yield:

: 5834-14-0
3-(4-methyl-thiophen-2-yl)-acrylic acid

Guidance literature:: 2-Formyl-4-methyl-thiophen, Malonsaeure;

Reference yield:

: 5834-14-0
3-(4-methyl-thiophen-2-yl)-acrylic acid

: 7-methyl-1-(2,4-dichlorophenyl)-N-menthyl-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen; palladium(II) hydroxide / ethanol / 18 h / 25 °C / 775.74 Torr

2: polyphosphoric acid / 1 h / 75 °C

3: sodium; ethanol / 5 h / 20 °C

4: acetic acid / 8 h / 110 °C

5: sodium hydroxide; water / ethanol / 5 h / 80 °C

6: thionyl chloride / dichloromethane / 5 h / 40 °C

7: dichloromethane / 2 h / 0 - 40 °C

With thionyl chloride; ethanol; water; hydrogen; sodium; palladium(II) hydroxide; acetic acid; sodium hydroxide; In ethanol; dichloromethane; 3: |Claisen Condensation;
DOI:10.1016/j.ejmech.2014.08.042