7-methyl-1-(2,4-dichlorophenyl)-N-(pyrrolidin-1-yl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide

Base Information

Chemical Name:7-methyl-1-(2,4-dichlorophenyl)-N-(pyrrolidin-1-yl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide
CAS No.:1623023-06-2
Molecular Formula:C₂₀H₁₈Cl₂N₄OS
Molecular Weight:433.361
Hs Code.:

Synonyms:7-methyl-1-(2,4-dichlorophenyl)-N-(pyrrolidin-1-yl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide

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Chemical Property of 7-methyl-1-(2,4-dichlorophenyl)-N-(pyrrolidin-1-yl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide

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Technology Process of 7-methyl-1-(2,4-dichlorophenyl)-N-(pyrrolidin-1-yl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide

There total 9 articles about 7-methyl-1-(2,4-dichlorophenyl)-N-(pyrrolidin-1-yl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₉Cl₃N₂OS

: 63234-71-9
1-aminopyrrolidine hydrochloride

: 1623023-06-2
7-methyl-1-(2,4-dichlorophenyl)-N-(pyrrolidin-1-yl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide

Guidance literature:: In dichloromethane; at 0 - 40 ℃; for 2h;
DOI:10.1016/j.ejmech.2014.08.042

Reference yield:

: 5834-14-0
3-(4-methyl-thiophen-2-yl)-acrylic acid

: 1623023-06-2
7-methyl-1-(2,4-dichlorophenyl)-N-(pyrrolidin-1-yl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen; palladium(II) hydroxide / ethanol / 18 h / 25 °C / 775.74 Torr

2: polyphosphoric acid / 1 h / 75 °C

3: sodium; ethanol / 5 h / 20 °C

4: acetic acid / 8 h / 110 °C

5: sodium hydroxide; water / ethanol / 5 h / 80 °C

6: thionyl chloride / dichloromethane / 5 h / 40 °C

7: dichloromethane / 2 h / 0 - 40 °C

With thionyl chloride; ethanol; water; hydrogen; sodium; palladium(II) hydroxide; acetic acid; sodium hydroxide; In ethanol; dichloromethane; 3: |Claisen Condensation;
DOI:10.1016/j.ejmech.2014.08.042

Reference yield:

: 1623023-31-3
7-methyl-1-(2,4-dichlorophenyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylic acid

: 1623023-06-2
7-methyl-1-(2,4-dichlorophenyl)-N-(pyrrolidin-1-yl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 5 h / 40 °C

2: dichloromethane / 2 h / 0 - 40 °C

With thionyl chloride; In dichloromethane;
DOI:10.1016/j.ejmech.2014.08.042