3-Amino-1-(4-fluorophenyl)pyrrolidin-2-one

Base Information

Chemical Name:3-Amino-1-(4-fluorophenyl)pyrrolidin-2-one
CAS No.:5301-36-0
Molecular Formula:C15H11BrN2OS
Molecular Weight:194.2055
Hs Code.:
DSSTox Substance ID:DTXSID90967496
Nikkaji Number:J51.464K

Synonyms:3-amino-1-(4-fluorophenyl)pyrrolidin-2-one;5301-36-0;BRN 0400091;3-Amino-1-(p-fluorophenyl)-2-pyrrolidinone;2-Pyrrolidinone, 3-amino-1-(p-fluorophenyl)-;2-Pyrrolidinone, 3-amino-1-(4-fluorophenyl)-;5-22-12-00469 (Beilstein Handbook Reference);SCHEMBL14275589;DTXSID90967496;AKOS010811415;CS-0242726;EN300-254334

Suppliers and Price of 3-Amino-1-(4-fluorophenyl)pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 3-Amino-1-(4-fluorophenyl)pyrrolidin-2-one

Chemical Property:

Vapor Pressure:1.12E-09mmHg at 25°C
Boiling Point:413°Cat760mmHg
Flash Point:203.6°C
Density:1.275g/cm³
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:194.08554114
Heavy Atom Count:14
Complexity:226

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C(=O)C1N)C2=CC=C(C=C2)F

Technology Process of 3-Amino-1-(4-fluorophenyl)pyrrolidin-2-one

There total 2 articles about 3-Amino-1-(4-fluorophenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 51779-32-9
iminodicarboxylic acid di-tert-butyl ester

: 1-(4-fluorophenyl)-3-hydroxypyrrolidin-2-one

: 5301-36-0
3-amino-1-(4-fluorophenyl)pyrrolidin-2-one

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; toluene; acetonitrile; at 20 ℃; for 27h;

Reference yield:

: 371-40-4
4-fluoroaniline

: 5301-36-0
3-amino-1-(4-fluorophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 24 h / 150 °C

2: diethylazodicarboxylate; triphenylphosphine / dichloromethane; toluene; acetonitrile / 27 h / 20 °C

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; toluene; acetonitrile;