1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(naphthalen-1-yloxy)propan-2-ol

Base Information

• Chemical Name: 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(naphthalen-1-yloxy)propan-2-ol
• CAS No.: 2347-27-5
• Molecular Formula: C23H27 N O4
• Molecular Weight: 381.4648
• Mol file: 2347-27-5.mol

Synonyms:2-Propanol,1-[(3,4-dimethoxyphenethyl)amino]-3-(1-naphthyloxy)- (7CI,8CI); N-3,4-Dimethoxyphenethylnaphthoxypropanolamine

Chemical Property of 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(naphthalen-1-yloxy)propan-2-ol

Chemical Property:

• Vapor Pressure: 2.36E-14mmHg at 25°C
• Boiling Point: 581.3°Cat760mmHg
• Flash Point: 305.4°C
• Density: 1.159g/cm³

Purity/Quality:

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MSDS Files:

SDS file from LookChem

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Technology Process of 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(naphthalen-1-yloxy)propan-2-ol

There total 3 articles about 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(naphthalen-1-yloxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(1-naphthyloxy)-1,2-epoxypropane (2461-42-9) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 1-(3,4-dimethoxyphenethylamino)-3-(naphthalen-1-yloxy)propan-2-ol (2347-27-5)

Guidance literature:

With cerium(III) chloride heptahydrate; glycerol; at 20 ℃; for 1h; regioselective reaction;

DOI:10.1055/s-0030-1258366

Reference yield:

1-chloro-3-(1-naphthoxy)-2-propanol (20133-93-1) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 1-(3,4-dimethoxyphenethylamino)-3-(naphthalen-1-yloxy)propan-2-ol (2347-27-5)

Guidance literature:

DOI:10.1021/jm00311a021

Reference yield:

→ 1-(3,4-dimethoxyphenethylamino)-3-(naphthalen-1-yloxy)propan-2-ol (2347-27-5)

Guidance literature:

entspr. 3-Aryloxy-1-chlor-propanol-(2), 3,4-Dimethoxy-phenaethylamin, 100grad;

DOI:10.1021/jm00236a007

upstream raw materials:

1-chloro-3-(1-naphthoxy)-2-propanol

2-(3,4-dimethoxyphenyl)-ethylamine

3-(1-naphthyloxy)-1,2-epoxypropane

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