1-Chloro-3-(1-naphthoxy)-2-propanol

Base Information

Chemical Name:1-Chloro-3-(1-naphthoxy)-2-propanol
CAS No.:20133-93-1
Molecular Formula:C13H13ClO2
Molecular Weight:236.698
Hs Code.:2909499000
European Community (EC) Number:243-538-3
NSC Number:91519
DSSTox Substance ID:DTXSID101273366
Nikkaji Number:J280.456E
Mol file:20133-93-1.mol

Synonyms:1-chloro-3-(1-naphthyloxy)-2-propanol;1-Cl-3-NP

Suppliers and Price of 1-Chloro-3-(1-naphthoxy)-2-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Chloro-3-(1-naphthyloxy)-2-propanol
10mg
$ 1320.00

American Custom Chemicals Corporation
1-(ALPHA-NAPHTHOXY)-3-CHLORO-2-PROPANOL 95.00%
5MG
$ 498.61

AK Scientific
1-Chloro-3-(1-naphthoxy)-2-propanol
500mg
$ 835.00

AK Scientific
1-Chloro-3-(1-naphthoxy)-2-propanol
250mg
$ 567.00

Total 11 raw suppliers

Chemical Property of 1-Chloro-3-(1-naphthoxy)-2-propanol

Chemical Property:

Vapor Pressure:1.46E-07mmHg at 25°C
Refractive Index:1.616
Boiling Point:413.1 °C at 760 mmHg
PKA:13.07±0.20(Predicted)
Flash Point:203.6 °C
PSA：29.46000
Density:1.246 g/cm³
LogP:2.81830
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:236.0604073
Heavy Atom Count:16
Complexity:210

Purity/Quality:

99% ^*data from raw suppliers

1-Chloro-3-(1-naphthyloxy)-2-propanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=CC=C2OCC(CCl)O
Uses 1-Chloro-3-(1-naphthyloxy)-2-propanol is an intermediates in the synthesis of β-adrenergic blocking agents and antihypertensive drugs such as propranolol and nadoxolol. Also used in the kinetic resolution studies of (±)-1-chloro-3-(1-naphthyloxy)-2-propanol in nonaqueous media using lipase-catalyzed esterification.

Technology Process of 1-Chloro-3-(1-naphthoxy)-2-propanol

There total 12 articles about 1-Chloro-3-(1-naphthoxy)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

: 90-15-3
α-naphthol

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 20133-93-1
1-chloro-3-(1-naphthoxy)-2-propanol

Guidance literature:: α-naphthol; epichlorohydrin; With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 0.333333h; Heating;

With hydrogenchloride; In dichloromethane; at 5 ℃; for 2h;
DOI:10.1016/S0045-2068(03)00050-6

Reference yield: 69.0%

: 90-15-3
α-naphthol

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 2461-42-9
3-(1-naphthyloxy)-1,2-epoxypropane

: 20133-93-1
1-chloro-3-(1-naphthoxy)-2-propanol

Guidance literature:: With sodium hydroxide; In water; for 6h; Heating;
DOI:10.1016/j.tet.2006.08.067

Reference yield: 29.0%

: 20009-25-0
allyl naphthyl ether

: 20133-93-1
1-chloro-3-(1-naphthoxy)-2-propanol

Guidance literature:: With μ-(R)-BINAP μ-1-phenylhexane-1,3,5-triketone bis[(acetonitrile)palladium(II)] tetrafluoroborate; oxygen; lithium chloride; copper dichloride; In tetrahydrofuran; water; at 23 ℃; for 240h; under 760.051 Torr; Reagent/catalyst; Sealed tube;
DOI:10.1021/acs.orglett.5b02650