1-{4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenyl}ethanol

Base Information

Chemical Name:1-{4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenyl}ethanol
CAS No.:55687-78-0
Molecular Formula:C15H20N4O3
Molecular Weight:304.3443
Hs Code.:

Synonyms:

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Chemical Property of 1-{4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenyl}ethanol

Chemical Property:

Vapor Pressure:5.16E-16mmHg at 25°C
Boiling Point:615.6°Cat760mmHg
Flash Point:326.1°C
Density:1.273g/cm³

Purity/Quality:

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Technology Process of 1-{4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenyl}ethanol

There total 8 articles about 1-{4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenyl}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 55687-76-8
4'-<(2,5-diamino-5-pyrimidinyl)methyl>-2',6'-dimethoxyacetophenone

: 55687-78-0
4-<(2,4-diamino-5-pyrimidinyl)methyl>-2,6-dimethoxy-α-methylbenzyl alcohol

Guidance literature:: With sodium tetrahydroborate; In methanol; sodium hydroxide;

Reference yield:

: 33187-98-3
3,5-dimethoxy-4-(methoxycarbonyl)benzaldehyde

: 55687-78-0
4-<(2,4-diamino-5-pyrimidinyl)methyl>-2,6-dimethoxy-α-methylbenzyl alcohol

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C

2: 95 percent / propan-2-ol / 0.5 h / Heating

3: 86 percent / sodium methylate / ethanol / 40 h / Heating

4: 1.) sodium hydride / 1.) DMF, 45 min, 65 deg C; 2.) THF-DMF, 60 deg C, 20 min

5: 58 percent / amalgamated alumina / tetrahydrofuran; H₂O / 5 h / 60 °C

6: 60 percent / sodium borohydride / methanol; aq. NaOH

With sodium tetrahydroborate; aluminium amalgam; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; sodium hydroxide; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 16849-68-6
dimethyl 2,6-dimethoxyterephthalate

: 55687-78-0
4-<(2,4-diamino-5-pyrimidinyl)methyl>-2,6-dimethoxy-α-methylbenzyl alcohol

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / sodium bis(2-methoxyethoxy)aluminum hyride, morpholine / toluene / 4 h / -15 °C

2: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C

3: 95 percent / propan-2-ol / 0.5 h / Heating

4: 86 percent / sodium methylate / ethanol / 40 h / Heating

5: 1.) sodium hydride / 1.) DMF, 45 min, 65 deg C; 2.) THF-DMF, 60 deg C, 20 min

6: 58 percent / amalgamated alumina / tetrahydrofuran; H₂O / 5 h / 60 °C

7: 60 percent / sodium borohydride / methanol; aq. NaOH

With morpholine; sodium tetrahydroborate; aluminium amalgam; sodium methylate; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; sodium hydroxide; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;