33187-98-3

Upstream product

• 16849-68-6 dimethyl 2,6-dimethoxyterephthalate 
• 55687-80-4 methyl 2,6-dimethoxy-4-(α,α-diethoxymethyl)benzoate 
• 140464-79-5 methyl 2,6-dimethoxy-4-dimethoxymethylbenzoate 
• 101403-71-8 3,4,5-Trimethoxybenzaldehyde diethyl acetal 

Downstream Products

• 55687-43-9 methyl 4-(2-cyano-3-morpholinoallyl)-2,6-dimethoxybenzoate 
• 55687-40-6 methyl α-(2,4-diamino-5-pyrimidinyl)-2,6-dimethoxy-p-toluate 
• 55687-80-4 methyl 2,6-dimethoxy-4-(α,α-diethoxymethyl)benzoate 
• 55687-45-1 α-(2,4-diamino-5-pyrimidinyl)-2,6-dimethoxy-p-toluic acid 
• 55687-47-3 4-(2,4-diamino-pyrimidin-5-ylmethyl)-2,6-dimethoxy-benzoic acid butyl ester 
• 55687-46-2 4-(2,4-diamino-pyrimidin-5-ylmethyl)-2,6-dimethoxy-benzoic acid isopropyl ester 
• 55687-76-8 4'-<(2,5-diamino-5-pyrimidinyl)methyl>-2',6'-dimethoxyacetophenone 
• 55687-91-7 2-[4-(2,4-diamino-pyrimidin-5-ylmethyl)-2,6-dimethoxy-phenyl]-propan-2-ol 
• 55687-78-0 4-<(2,4-diamino-5-pyrimidinyl)methyl>-2,6-dimethoxy-α-methylbenzyl alcohol 
• 55687-49-5 4-<(2,4-diamino-5-pyrimidinyl)methyl>-1,6-dimethoxybenzyl alcohol 
• 55687-96-2 3-[4-(2,4-diamino-pyrimidin-5-ylmethyl)-2,6-dimethoxy-phenyl]-pentan-3-ol 
• 55687-86-0 2,4-diamino-5-<3,5-dimethoxy-4-(methoxymethyl)benzyl>-pyrimidine 
• 74731-66-1 5-(4-Isopropyl-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine 
• 55687-75-7 4'-<(2,4-diamino-5-pyrimidinyl)methyl>-2',6'-dimethoxy-2-methylsulfonyl acetophenone hydrochloride 

Relevant academic research and scientific papers

Regioselective Reductive Electrophilic Substitution of Derivatives of 3,4,5-Trimethoxybenzaldehyde

The behavior of several protected derivatives of 3,4,5-trimethoxybenzaldehyde has been investigated under conditions of electron transfer from alkali metals in aprotic solvents.The 4-methoxy group can be regioselectively removed in good to high yield under such conditions, and an appropriate choice of the protecting group, metal, and solvent allows its substitution with a variety of electrophiles. 3,4,5-Trimethoxybenzaldehyde dimethyl acetal, 1, is the starting material of choice for a new general synthetic approach to several polysubstituted resorcinol dimethyl ethers.Investigation of the mechanism of demethoxymetylation, with the aid of labeling experiments, showed that reductive demethoxylation is strongly influenced by the nature of the aldehyde protective group employed.

Synthesis and antimicrobial activity of C(4')-substituted analogs of trimethoprim

A series of 2,4-diamino-5-(3,5-dimethoxybenzyl)-pyrimidines substitute at C(4') of the benzene ring with a functionalized carbon atom was synthesized. The target substances were tested for inhibition of dihydrofolate reductases from E. coli and rat liver,

2,4-Diamino-5-benzylpyrimidines

2,4-Diamino-5-benzylpyrimidines characterized by the formula SPC1 Wherein R1, R2, A1, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they block bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.