5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one

Base Information

• Chemical Name: 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one
• CAS No.: 33671-37-3
• Molecular Formula: C15H13ClN2OS
• Molecular Weight: 304.8
• Mol file: 33671-37-3.mol

Synonyms:

Chemical Property of 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one

Chemical Property:

• Vapor Pressure: 4.23E-12mmHg at 25°C
• Melting Point: 208-210°C (dec.)
• Boiling Point: 548.9°Cat760mmHg
• PKA: 13.08±0.40(Predicted)
• Flash Point: 285.8°C
• PSA: 69.70000
• Density: 1.39g/cm³
• LogP: 3.32700
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N-Desmethyl Clotiazepam ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Desmethylclotiazepam (Item No. 27838) is an analytical reference standard categorized as a thienodiazepine. It is an active metabolite of clotiazepam. This product is intended for research and forensic applications.
• Uses: Clotiazepam (C587410) metabolite, with central nervous depressant and anxiolytic activity.

Technology Process of 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one

There total 2 articles about 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(Aminoacetamido)-3-(2-Chlorobenzoyl)-5-ethylthiophene (50509-09-6) → 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]1,4-diazepin-2-one (33671-37-3)

Guidance literature:

With acetic acid; In pyridine; benzene;

DOI:10.1021/jm00261a010

Reference yield:

→ 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]1,4-diazepin-2-one (33671-37-3)

Guidance literature:

Reference yield:

5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]1,4-diazepin-2-one (33671-37-3) + methyl iodide (74-88-4) → clotiazepam (33671-46-4)

Guidance literature:

Multistep reaction; (i) NaH, DMF, (ii) /BRN= 969135/;

DOI:10.1021/jm00261a010

upstream raw materials:

2-(Aminoacetamido)-3-(2-Chlorobenzoyl)-5-ethylthiophene

Downstream raw materials:

clotiazepam

5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-thione

1-[4-(2-chloro-phenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-ethanone

5-(2-chloro-phenyl)-7-ethyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one propionylhydrazone