N-D-Phenylalanyl-D-tryptophan methyl ester hydrochloride

Base Information

Chemical Name:N-D-Phenylalanyl-D-tryptophan methyl ester hydrochloride
CAS No.:76327-08-7
Molecular Formula:C₂₁H₂₃N₃O₃*ClH
Molecular Weight:401.893
Hs Code.:
DSSTox Substance ID:DTXSID60227190

Synonyms:N-D-Phenylalanyl-D-tryptophan methyl ester hydrochloride;D-Tryptophan, N-D-phenylalanyl-, methyl ester, monohydrochloride;76327-08-7;DTXSID60227190;LS-158164

Suppliers and Price of N-D-Phenylalanyl-D-tryptophan methyl ester hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-D-Phenylalanyl-D-tryptophan methyl ester hydrochloride

Chemical Property:

Vapor Pressure:6.32E-16mmHg at 25°C
Boiling Point:632.9°Cat760mmHg
Flash Point:336.6°C
Density:g/cm³
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:401.1506193
Heavy Atom Count:28
Complexity:507

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CC3=CC=CC=C3)N.Cl
Isomeric SMILES:COC(=O)[C@@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H](CC3=CC=CC=C3)N.Cl

Technology Process of N-D-Phenylalanyl-D-tryptophan methyl ester hydrochloride

There total 7 articles about N-D-Phenylalanyl-D-tryptophan methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 83522-39-8
N^α-(tert-butoxycarbonyl)-L-phenylalanyl-L-tryptophan methyl ester

: 76327-08-7
L-phenylalaninyl-L-triptophane methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 5h;
DOI:10.1016/j.tet.2006.05.010

Reference yield:

: 123910-21-4
methyl ((benzyloxy)carbonyl)-L-phenylalanyl-D-tryptophanate

: 76327-08-7
(R)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; under 760 Torr;
DOI:10.1021/jm00089a011

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 76327-08-7
(R)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 91.9 percent / 1-hydroxybenzotriazole, 1-ethyl-3-<3-N,N-dimethylamino)propyl>carbodiimide / CH₂Cl₂; dimethylformamide / 3 h

2: 1 N HCl, H₂ / 10percent Pd/C / methanol; H₂O / 760 Torr

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00089a011