1-(10H-Phenothiazin-2-yl)ethanone

Base Information Edit

Chemical Name:1-(10H-Phenothiazin-2-yl)ethanone
CAS No.:6631-94-3
Molecular Formula:C14H11 N O S
Molecular Weight:241.313
Hs Code.:2934300000
European Community (EC) Number:229-626-4
NSC Number:169669,57951
UNII:8DEE7H3XAB
DSSTox Substance ID:DTXSID20216525
Nikkaji Number:J124.130C
Wikidata:Q27164209
Pharos Ligand ID:JG7A3VFLU18H
ChEMBL ID:CHEMBL407734
Mol file:6631-94-3.mol

Synonyms:1-(10H-phenothiazin-2-yl)ethanone

Suppliers and Price of 1-(10H-Phenothiazin-2-yl)ethanone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ML 171
50mg
$ 290.00

TRC
2-AcetylPhenothiazine
25g
$ 95.00

TCI Chemical
2-Acetylphenothiazine >98.0%(GC)
5g
$ 122.00

TCI Chemical
2-Acetylphenothiazine >98.0%(GC)
25g
$ 354.00

SynQuest Laboratories
2-Acetyl-10H-phenothiazine
100 g
$ 295.00

SynQuest Laboratories
2-Acetyl-10H-phenothiazine
5 g
$ 65.00

SynQuest Laboratories
2-Acetyl-10H-phenothiazine
25 g
$ 195.00

Sigma-Aldrich
NOX1 Inhibitor, ML171
10mg
$ 92.60

Sigma-Aldrich
2-Acetylphenothiazine 95%
100g
$ 241.00

Sigma-Aldrich
2-Acetylphenothiazine 95%
25g
$ 145.00

Total 70 raw suppliers

Chemical Property of 1-(10H-Phenothiazin-2-yl)ethanone Edit

Chemical Property:

Appearance/Colour:mustard-colored powder
Vapor Pressure:1.72E-08mmHg at 25°C
Melting Point:190 - 193 C
Boiling Point:455.7 °C at 760 mmHg
PKA:-2.45±0.20(Predicted)
Flash Point:229.4 °C
PSA：54.40000
Density:1.249 g/cm³
LogP:4.23540
Storage Temp.:+2C to +8C
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:241.05613515
Heavy Atom Count:17
Complexity:307

Purity/Quality:

99.9% ^*data from raw suppliers

ML 171 ^*data from reagent suppliers

Safty Information:

Pictogram(s): UN NO.
Hazard Codes:Xn
Statements: 22-52/53
Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2
Description 2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.
Uses 2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells. 2-Acetylphenothiazine was used as a NADPH oxidase (NOX) inhibitor in human platelet functional responses and intracellular signaling pathways. It was also used in the synthesis of 2-phenothiazin-2′-yl-cinchoninic acid derivatives.

Technology Process of 1-(10H-Phenothiazin-2-yl)ethanone

There total 18 articles about 1-(10H-Phenothiazin-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%