23699-65-2

Basic information

• Product Name: 1-(3-PHENYLAMINO-PHENYL)-ETHANONE
• Synonyms: 1-(3-PHENYLAMINO-PHENYL)-ETHANONE
• CAS NO: 23699-65-2
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.25912
• Mol File: 23699-65-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 154 °C
• Boiling Point: 367.8°C at 760 mmHg
• Flash Point: 148.4°C
• Appearance: /
• Density: 1.129g/cm³
• Vapor Pressure: 1.33E-05mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.23±0.30(Predicted)
• CAS DataBase Reference: 1-(3-PHENYLAMINO-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-PHENYLAMINO-PHENYL)-ETHANONE(23699-65-2)
• EPA Substance Registry System: 1-(3-PHENYLAMINO-PHENYL)-ETHANONE(23699-65-2)

Safety Data

• Hazardous Substances Data: 23699-65-2(Hazardous Substances Data)

Usage

General Description

1-(3-Phenylamino-phenyl)-ethanone, also known as 3-phenthylaminophenyl ethanone, is a chemical compound with the molecular formula C16H15NO. It is a pale yellow solid with a molecular weight of 237.30 g/mol. 1-(3-PHENYLAMINO-PHENYL)-ETHANONE is used in the field of organic synthesis and pharmaceutical research as a reagent and intermediate. It has also been studied for its potential pharmacological properties, particularly as an analgesic and anti-inflammatory agent. Its aromatic and ketone functional groups make it a versatile building block for the synthesis of diverse organic compounds. Additionally, 1-(3-Phenylamino-phenyl)-ethanone is used as a research tool in the study of molecular interactions and biological processes, making it a valuable chemical for various scientific investigations.

InChI:InChI=1/C14H13NO/c1-11(16)12-6-5-9-14(10-12)15-13-7-3-2-4-8-13/h2-10,15H,1H3

Upstream product

• 27696-28-2 N-(3-acetylphenyl)anthranilic acid 
• 62-53-3 aniline 
• 99-02-5 3'-Chloroacetophenone 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 98-80-6 phenylboronic acid 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 16463-38-0 potassium 2-chlorobenzoate 
• 121-71-1 3-Hydroxyacetophenone 
• 103-70-8 Formanilid 
• 108-94-1 cyclohexanone 
• 108-95-2 phenol 
• 58297-34-0 3-acetylphenyl p-toluenesulfonate 
• 105333-30-0 1-(3-nitrosophenyl)ethan-1-one 
• 586-96-9 Nitrosobenzene 

Downstream Products

• 6631-94-3 2-acetylphenothiazine 

Relevant articles and documents

Continuous Synthesis of Aryl Amines from Phenols Utilizing Integrated Packed-Bed Flow Systems

Aryl amines are important pharmaceutical intermediates among other numerous applications. Herein, an environmentally benign route and novel approach to aryl amine synthesis using dehydrative amination of phenols with amines and styrene under continuous-flow conditions was developed. Inexpensive and readily available phenols were efficiently converted into the corresponding aryl amines, with small amounts of easily removable co-products (i.e., H2O and alkanes), in multistep continuous-flow reactors in the presence of heterogeneous Pd catalysts. The high product selectivity and functional-group tolerance of this method allowed aryl amines with diverse functional groups to be selectively obtained in high yields over a continuous operation time of one week.

Synthesis of Di(hetero)arylamines from Nitrosoarenes and Boronic Acids: A General, Mild, and Transition-Metal-Free Coupling

The synthesis of di(hetero)arylamines by a transition-metal-free cross-coupling between nitrosoarenes and boronic acids is reported. The procedure is experimentally simple, fast, mild, and scalable and has a wide functional group tolerance, including carbonyls, nitro, halogens, free OH and NH groups. It also permits the synthesis of sterically hindered compounds.

Method for synthesis of 2-acetyl phenothiazine with m-acetyl phenol and aniline as raw materials

The invention discloses to a method for synthesis of 2-acetyl phenothiazine with m-acetyl phenol and aniline as raw materials. The method comprises the steps: carrying out a dehydration reaction of m-acetyl phenol and aniline with trifluoromethanesulfonic acid as a catalyst; and carrying out an annulation reaction on the product obtained in the first step with elemental sulfur under the catalysis of iodine in an acetone solvent. With m-acetyl phenol and aniline as the raw materials, firstly, amino and phenolic hydroxyl are subjected to dehydration reaction, then the product is subjected to annulation reaction with elemental sulfur, and thus 2-acetyl phenothiazine is obtained. Trifluoromethanesulfonic acid as the dehydration reaction catalyst has stronger acidity and has the effect of relatively strongly protonizing m-acetyl phenol to form a molten salt, and the dehydration yield is increased. Through the two steps, the total yield and purity of 2-acetyl phenothiazine are ensured.