1-(4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxyphenyl)ethanone oxime

Base Information

Chemical Name:1-(4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxyphenyl)ethanone oxime
CAS No.:74731-65-0
Molecular Formula:C15H19N5O3
Molecular Weight:317.3431
Hs Code.:

Synonyms:BRN 5994244;1-(4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxyphenyl)ethanone oxime;4'-((2,4-Diamino-5-pyrimidinyl)methyl)-2',6'-dimethoxyacetophenone oxime;Ethanone, 1-(4-((2,4-diamino-5-pyrimidinyl)methyl)-2,6-dimethoxyphenyl)-, oxime;74731-65-0;C15H19N5O3;C15-H19-N5-O3;LS-67306

Suppliers and Price of 1-(4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxyphenyl)ethanone oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxyphenyl)ethanone oxime

Chemical Property:

Vapor Pressure:5.8E-17mmHg at 25°C
Boiling Point:634.4°Cat760mmHg
Flash Point:337.4°C
Density:1.36g/cm³
XLogP3:1.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:317.14878949
Heavy Atom Count:23
Complexity:395

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=NO)C1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC
Isomeric SMILES:C/C(=N/O)/C1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC

Technology Process of 1-(4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxyphenyl)ethanone oxime

There total 6 articles about 1-(4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxyphenyl)ethanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 55687-76-8
4'-<(2,5-diamino-5-pyrimidinyl)methyl>-2',6'-dimethoxyacetophenone

: 74731-65-0
4'-<(2,5-diamino-5-pyrimidinyl)methyl>-2',6'-dimethoxyacetophenone oxime

Guidance literature:: With pyridine; hydroxylamine hydrochloride; In ethanol; for 4h; Heating;

Reference yield:

: 33187-98-3
3,5-dimethoxy-4-(methoxycarbonyl)benzaldehyde

: 74731-65-0
4'-<(2,5-diamino-5-pyrimidinyl)methyl>-2',6'-dimethoxyacetophenone oxime

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C

2: 95 percent / propan-2-ol / 0.5 h / Heating

3: 86 percent / sodium methylate / ethanol / 40 h / Heating

4: 1.) sodium hydride / 1.) DMF, 45 min, 65 deg C; 2.) THF-DMF, 60 deg C, 20 min

5: 58 percent / amalgamated alumina / tetrahydrofuran; H₂O / 5 h / 60 °C

6: 80 percent / hydroxylamine hydrochloride, pyridine / ethanol / 4 h / Heating

With pyridine; aluminium amalgam; hydroxylamine hydrochloride; sodium methylate; sodium hydride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 16849-68-6
dimethyl 2,6-dimethoxyterephthalate

: 74731-65-0
4'-<(2,5-diamino-5-pyrimidinyl)methyl>-2',6'-dimethoxyacetophenone oxime

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / sodium bis(2-methoxyethoxy)aluminum hyride, morpholine / toluene / 4 h / -15 °C

2: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C

3: 95 percent / propan-2-ol / 0.5 h / Heating

4: 86 percent / sodium methylate / ethanol / 40 h / Heating

5: 1.) sodium hydride / 1.) DMF, 45 min, 65 deg C; 2.) THF-DMF, 60 deg C, 20 min

6: 58 percent / amalgamated alumina / tetrahydrofuran; H₂O / 5 h / 60 °C

7: 80 percent / hydroxylamine hydrochloride, pyridine / ethanol / 4 h / Heating

With morpholine; pyridine; aluminium amalgam; hydroxylamine hydrochloride; sodium methylate; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;