4-Acetyl-2-(2-aminoethyl)-5,6-bis(4-chlorophenyl)pyridazin-3-one;hydrobromide

Base Information

Chemical Name:4-Acetyl-2-(2-aminoethyl)-5,6-bis(4-chlorophenyl)pyridazin-3-one;hydrobromide
CAS No.:75644-09-6
Molecular Formula:BrH*C₂₀H₁₇Cl₂N₃O₂
Molecular Weight:483.192
Hs Code.:
ChEMBL ID:CHEMBL544228
DSSTox Substance ID:DTXSID70506943
NSC Number:351630

Synonyms:75644-09-6;CHEMBL544228;SCHEMBL11439384;DTXSID70506943;NSC351630;NSC-351630;4-Acetyl-2-(2-aminoethyl)-5,6-bis(4-chlorophenyl)pyridazin-3(2H)-one--hydrogen bromide (1/1)

Suppliers and Price of 4-Acetyl-2-(2-aminoethyl)-5,6-bis(4-chlorophenyl)pyridazin-3-one;hydrobromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of 4-Acetyl-2-(2-aminoethyl)-5,6-bis(4-chlorophenyl)pyridazin-3-one;hydrobromide

Chemical Property:

Vapor Pressure:5.69E-13mmHg at 25°C
Boiling Point:569.2°Cat760mmHg
Flash Point:298.1°C
Density:1.37g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:480.99594
Heavy Atom Count:28
Complexity:646

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=C(C(=NN(C1=O)CCN)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl.Br

Technology Process of 4-Acetyl-2-(2-aminoethyl)-5,6-bis(4-chlorophenyl)pyridazin-3-one;hydrobromide

There total 3 articles about 4-Acetyl-2-(2-aminoethyl)-5,6-bis(4-chlorophenyl)pyridazin-3-one;hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 75643-87-7
2-{2-[5-Acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl}-isoindole-1,3-dione

: 75644-09-6
2-(2'-aminoethyl)-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one(hydrobromide)

Guidance literature:: With hydrogen bromide; acetic acid; for 24h; Heating;
DOI:10.1021/jm00186a021

Reference yield:

: 75643-31-1
4-Acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one

: 75644-09-6
2-(2'-aminoethyl)-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one(hydrobromide)

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / anhyd. K₂CO₃ / dimethylformamide / 3 h / 80 - 100 °C

2: 30 percent / 48percent HBr, glacial acetic acid / 24 h / Heating

With hydrogen bromide; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00186a021