75643-31-1

Upstream product

• 40036-75-7 (E)-4,4'-dichlorobenzil monohydrazone 
• 141-97-9 ethyl acetoacetate 
• 168555-53-1 4-acetyl-6-chloro-5-iodo-3-methoxypyridazine 
• 168555-52-0 6-chloro-4-(1-hydroxyethyl)-5-iodo-3-methoxypyridazine 
• 1679-18-1 4-Chlorophenylboronic acid 

Downstream Products

• 75319-92-5 2-(2'-hydroxyethyl)-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one 
• 75643-87-7 2-{2-[5-Acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl}-isoindole-1,3-dione 
• 75644-03-0 2-{6-[5-Acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-hexyl}-isoindole-1,3-dione 
• 78613-01-1 4-acetyl-3-chloro-5,6-bis(4-chlorophenyl)pyridazine 
• 75643-84-4 4-Acetyl-5,6-bis-(4-chloro-phenyl)-2-oxiranylmethyl-2H-pyridazin-3-one 
• 75643-83-3 4-Acetyl-2-(3-chloro-2-hydroxy-propyl)-5,6-bis-(4-chloro-phenyl)-2H-pyridazin-3-one 
• 75643-98-0 4-Acetyl-5,6-bis-(4-chloro-phenyl)-2-ethyl-2H-pyridazin-3-one 
• 75643-80-0 4-Acetyl-5,6-bis-(4-chloro-phenyl)-2-(2-oxo-propyl)-2H-pyridazin-3-one 
• 75643-73-1 4-Acetyl-5,6-bis-(4-chloro-phenyl)-2-(2-hydroxy-1-methyl-ethyl)-2H-pyridazin-3-one 
• 75643-70-8 4-Acetyl-5,6-bis-(4-chloro-phenyl)-2-(2-hydroxy-propyl)-2H-pyridazin-3-one 
• 75643-90-2 2-[5-Acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-acetamide 
• 75644-02-9 4-Acetyl-5,6-bis-(4-chloro-phenyl)-2-(5-hydroxy-pentyl)-2H-pyridazin-3-one 
• 75643-85-5 4-Acetyl-5,6-bis-(4-chloro-phenyl)-2-(3-dimethylamino-propyl)-2H-pyridazin-3-one 
• 75643-79-7 [5-Acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

A new route of 5,6-diarylpyridazin-3-ones by metalation and cross-coupling of pyridazines

Starting from 3,6-dichloropyridazine, a new route is described to antihypertensive 5,6-diarylpyridazin-3-ones. This pathway comprises the regioselective metalation followed by a substitution of the trimethylsilyl moiety. The introduction of iodine by anot

Isolation and identification of impurities in 4-acetyl-2-(2'-hydroxyethyl)-5,6-bis (4-chlorophenyl)- 2H-pyridazin-3-one, an antihypertensive agent

Three trace impurities found in 4-acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one (II), a novel antihypertensive agent, were isolated by a combination of low-pressure liquid chromatography and preparative TLC. These impurities were i

Synthesis of pyridazinone pharmaceutical intermediates using diketene reactant

Valuable pyridazinone intermediates to pharmaceutically useful compounds can be prepared in surprisingly high yields by the reaction of the corresponding monohydrazone with diketene, preferably in the presence of a basic catalyst. In an especially preferred embodiment, p,p'-dichlorobenzil monohydrazone and diketene are reacted in a xylene solvent in the presence of triethylamine to afford 4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one, which can then be reacted with ethylene carbonate in the presence of potassium carbonate to afford the antihypertensive agent, 4-acetyl-5,6-bis(p-chlorophenyl)-2-(2'-hydroxyethyl)-2H-pyridazine-3-one.

Quinoline catalyzed synthesis of pyridazinone pharmaceutical intermediates

Valuable pyridazinone intermediates to pharmaceutically useful compounds can be prepared in surprisingly high yields by the quinoline catalyzed reaction of the corresponding monohydrazone with an appropriately substituted acetic acid ester. In an especially preferred embodiment, p,p'-dichlorobenzil monohydrazone and methyl acetoacetate are reacted in a xylene solvent in the presence of quinoline to afford 4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one, which can then be reacted with ethylene carbonate in the presence of potassium carbonate to afford the antihypertensive agent, 4-acetyl-5,6-bis(p-chlorophenyl)-2-(2'-hydroxyethyl)-2H-pyridazin-3-one.

Antihypertensive pyridazin(2H)-3-ones

Compounds of the formula STR1 are useful antihypertensive agents.

Antihypertensive 5,6-diarylpyridazin-3-ones

The synthesis of a series of 5,6-diarylpyridazinones is described. Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat model and the deoxycorticosteroid (DOCA) model of hypertension. The most potent co