Synonyms:vinyl iodide
97% *data from raw suppliers
Vinyl iodide *data from reagent suppliers
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There total 21 articles about Vinyl iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 100.0%
Reference yield: 96.0%
Reference yield: 78.0%
The research aims to develop an efficient synthetic route for the C(7)-C(23) fragment of iriomoteolide-1a, a potent cytotoxic 20-membered ring macrolide with significant biological activity against human B lymphocyte cells. The study employs a B-alkyl Suzuki-Miyaura cross-coupling reaction as a key step, followed by deprotection and cyclization to form the cyclic hemiketal core. Key chemicals used include vinyl iodide 3, alkyl iodide 4, and various reagents such as LiAlH4 for reduction, DIBAL-H for selective reduction, and HF·pyridine for cyclization. The research concludes that the C(7)-C(23) fragment was successfully synthesized in an efficient manner, representing the most advanced intermediate en route to the natural product. The study also highlights the versatility of aldehyde 20 as a crucial intermediate and demonstrates the viability of late-stage hemiketal formation. Ongoing efforts are directed towards completing the total synthesis of iriomoteolide-1a.
The study presents a stereocontrolled synthesis of the A/B-ring fragment of gambieric acid B, a marine polycyclic ether natural product with potent antifungal activity. The researchers aimed to reassign the absolute configuration of the polycyclic ether region of gambieric acid B by comparing the 1H and 13C NMR data of synthesized fragments with those of the natural product. Key chemicals used in the study include alcohol 2, alkylborate 3, vinyl iodide 4, and allylic alcohol 5, which were synthesized through a series of reactions involving Sharpless asymmetric epoxidation, Suzuki-Miyaura coupling, and other organic synthesis techniques. These chemicals served as intermediates and building blocks in the construction of the A/B-ring fragment, ultimately leading to the synthesis of three possible diastereomers (1a-d) to determine the correct stereochemistry. The study concluded that the original stereochemical assignment of gambieric acid B should be revised, with 1c being an enantiomer of the A/B-ring fragment, indicating the opposite configuration of the polycyclic ether region compared to the initial assignment.
The research describes the total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide. The hybrid was designed to have enhanced cell growth inhibitory activity compared to discodermolide, and it was found to retain this potent activity even against the Taxol-resistant NCI/ADR-Res cell line. The synthesis involved a series of chemical reactions, including a cross-coupling–macrolactonisation endgame, a Still–Gennari ole?nation, and a copper-mediated Stille cross-coupling. Key chemicals used in the synthesis include aldehyde 47, b-ketophosphonate 5, lactate-derived ketone 79, aldehyde 8, vinyl iodide 14, stannane 6, and various reagents for reduction, hydrolysis, and protection steps. The resulting hybrid 3 demonstrated low nanomolar cell growth inhibitory activity in vitro against four human cancer cell lines, suggesting its potential as a novel anticancer agent. The study also explored the contribution of the C7,C9-diol to the pharmacophore by synthesizing and testing an acetonide derivative 15, which had significantly reduced cytotoxicity.
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