6-(4-Chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo(2,1-b)-1,3,4-thiadiazole

Base Information

Chemical Name:6-(4-Chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo(2,1-b)-1,3,4-thiadiazole
CAS No.:91918-57-9
Molecular Formula:C₁₉H₁₆ClN₃O₃S
Molecular Weight:401.873
Hs Code.:
DSSTox Substance ID:DTXSID90919450
Wikidata:Q82891963

Synonyms:6-(4-Chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo(2,1-b)-1,3,4-thiadiazole;Imidazo(2,1-b)-1,3,4-thiadiazole, 6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)-;91918-57-9;C19H16ClN3O3S;DTXSID90919450;C19-H16-Cl-N3-O3-S;6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole;LS-80577

Suppliers and Price of 6-(4-Chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo(2,1-b)-1,3,4-thiadiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 6-(4-Chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo(2,1-b)-1,3,4-thiadiazole

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.4g/cm³
XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:401.0600902
Heavy Atom Count:27
Complexity:483

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C2=NN3C=C(N=C3S2)C4=CC=C(C=C4)Cl

Technology Process of 6-(4-Chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo(2,1-b)-1,3,4-thiadiazole

There total 2 articles about 6-(4-Chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo(2,1-b)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 28004-59-3
2-(3,4,5-trimethoxyphenyl)-5-amino-1,3,4-thiadiazole

: 536-38-9
4-chlorobenzoylmethyl bromide

: 91918-57-9
6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole

Guidance literature:: In ethanol; N,N-dimethyl-formamide; Reflux;
DOI:10.1002/cmdc.201400069

Reference yield:

: 118-41-2
Eudesmic acid

: 91918-57-9
6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / water / 4.5 h / 75 - 110 °C

2: N,N-dimethyl-formamide; ethanol / Reflux

With trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201400069

Reference yield: 76.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 91918-57-9
6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole

: 1356166-74-9
6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole-6-carbaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; In chloroform; at 0 - 5 ℃;

6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole; In chloroform; Cooling; Reflux;
DOI:10.1002/cmdc.201400069