1',2',3',4',5',6'-hexahydrohomofolic acid

Base Information

• Chemical Name: 1',2',3',4',5',6'-hexahydrohomofolic acid
• CAS No.: 83704-88-5
• Molecular Formula: C20H27 N7 O6
• Molecular Weight: 461.47168
• Mol file: 83704-88-5.mol

Synonyms:1’,2’,3’,4’,5’,6’-hexahydrohomofolic acid

Chemical Property of 1',2',3',4',5',6'-hexahydrohomofolic acid

Chemical Property:

• PSA: 213.28000
• Density: 1.66g/cm³
• LogP: 0.78340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1',2',3',4',5',6'-hexahydrohomofolic acid

There total 18 articles about 1',2',3',4',5',6'-hexahydrohomofolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-({4-[{2-[4-Oxo-2-(2,2,2-trifluoro-acetylamino)-3,4-dihydro-pteridin-6-yl]-ethyl}-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarbonyl}-amino)-pentanedioic acid diethyl ester → 1',2',3',4',5',6'-hexahydrohomofolic acid (83704-88-5)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 25 ℃; for 6h; Yield given;

DOI:10.1021/jm00356a004

Reference yield:

3-((4-(ethoxycarbonyl)phenyl)amino)propanoic acid (6959-76-8) → 1',2',3',4',5',6'-hexahydrohomofolic acid (83704-88-5)

Guidance literature:

Multi-step reaction with 18 steps

1: 100 percent / H₂ / PtO₂ / acetic acid / 18 h / 2327.2 Torr

2: 90 percent / 18 h / Ambient temperature

3: thionyl chloride / benzene / 1 h / Heating

4: diethyl ether / 1 h / 25 °C

5: HBr / diethyl ether

6: 91 percent / sodium azide / methanol; H₂O / 3.5 h / Ambient temperature

7: p-toluenesulfonic acid / benzene / 6 h / Heating

8: H₂ / 10percent Pd/C / 18 h / 517.1 Torr

9: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h

10: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C

11: 70 percent / sodium ditionite / dimethylformamide; H₂O / 0.33 h / 55 °C

12: pyridine, concd. HCl / methanol / 1 h / Heating

13: air / methanol / 4 h

14: 550 mg / 0.1 M NaOH / acetonitrile / 6 h / 25 °C

15: 93 percent / trifluoroacetic acid / 6 h

16: N-methylmorpholine / dimethylformamide / 0.58 h

17: N-methylmorpholine / dimethylformamide / 18 h / 25 °C

18: 0.1 N NaOH / acetonitrile / 6 h / 25 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sodium dithionite; air; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; platinum(IV) oxide; palladium on activated charcoal; In methanol; diethyl ether; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1021/jm00356a004

Reference yield:

N-(4-carbethoxycyclohexyl)-β-alanine (83704-89-6) → 1',2',3',4',5',6'-hexahydrohomofolic acid (83704-88-5)

Guidance literature:

Multi-step reaction with 17 steps

1: 90 percent / 18 h / Ambient temperature

2: thionyl chloride / benzene / 1 h / Heating

3: diethyl ether / 1 h / 25 °C

4: HBr / diethyl ether

5: 91 percent / sodium azide / methanol; H₂O / 3.5 h / Ambient temperature

6: p-toluenesulfonic acid / benzene / 6 h / Heating

7: H₂ / 10percent Pd/C / 18 h / 517.1 Torr

8: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h

9: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C

10: 70 percent / sodium ditionite / dimethylformamide; H₂O / 0.33 h / 55 °C

11: pyridine, concd. HCl / methanol / 1 h / Heating

12: air / methanol / 4 h

13: 550 mg / 0.1 M NaOH / acetonitrile / 6 h / 25 °C

14: 93 percent / trifluoroacetic acid / 6 h

15: N-methylmorpholine / dimethylformamide / 0.58 h

16: N-methylmorpholine / dimethylformamide / 18 h / 25 °C

17: 0.1 N NaOH / acetonitrile / 6 h / 25 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sodium dithionite; air; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1021/jm00356a004

upstream raw materials:

3-((4-(ethoxycarbonyl)phenyl)amino)propanoic acid

N-(4-carbethoxycyclohexyl)-β-alanine

1',2,',3',4',5',6'-hexahydrohomopteroic acid

1-bromo-4-butane-2-one