Technology Process of 1',2,',3',4',5',6'-hexahydrohomopteroic acid
There total 14 articles about 1',2,',3',4',5',6'-hexahydrohomopteroic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
acetonitrile;
at 25 ℃;
for 6h;
DOI:10.1021/jm00356a004
- Guidance literature:
-
Multi-step reaction with 14 steps
1: 100 percent / H2 / PtO2 / acetic acid / 18 h / 2327.2 Torr
2: 90 percent / 18 h / Ambient temperature
3: thionyl chloride / benzene / 1 h / Heating
4: diethyl ether / 1 h / 25 °C
5: HBr / diethyl ether
6: 91 percent / sodium azide / methanol; H2O / 3.5 h / Ambient temperature
7: p-toluenesulfonic acid / benzene / 6 h / Heating
8: H2 / 10percent Pd/C / 18 h / 517.1 Torr
9: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h
10: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C
11: 70 percent / sodium ditionite / dimethylformamide; H2O / 0.33 h / 55 °C
12: pyridine, concd. HCl / methanol / 1 h / Heating
13: air / methanol / 4 h
14: 550 mg / 0.1 M NaOH / acetonitrile / 6 h / 25 °C
With
4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sodium dithionite; air; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid;
platinum(IV) oxide; palladium on activated charcoal;
In
methanol; diethyl ether; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm00356a004
- Guidance literature:
-
Multi-step reaction with 13 steps
1: 90 percent / 18 h / Ambient temperature
2: thionyl chloride / benzene / 1 h / Heating
3: diethyl ether / 1 h / 25 °C
4: HBr / diethyl ether
5: 91 percent / sodium azide / methanol; H2O / 3.5 h / Ambient temperature
6: p-toluenesulfonic acid / benzene / 6 h / Heating
7: H2 / 10percent Pd/C / 18 h / 517.1 Torr
8: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h
9: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C
10: 70 percent / sodium ditionite / dimethylformamide; H2O / 0.33 h / 55 °C
11: pyridine, concd. HCl / methanol / 1 h / Heating
12: air / methanol / 4 h
13: 550 mg / 0.1 M NaOH / acetonitrile / 6 h / 25 °C
With
4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sodium dithionite; air; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm00356a004
![4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester](/Databaselist/images/loading.webp)
