Ethyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

Base Information

• Chemical Name: Ethyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
• CAS No.: 42019-08-9
• Molecular Formula: C19H19ClO4
• Molecular Weight: 346.81
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID70962166
• Nikkaji Number: J69.144E
• Wikidata: Q82943781
• Mol file: 42019-08-9.mol

Synonyms:42019-08-9;Fenofibric acid ethyl ester;ethyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate;BRN 2061574;2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid ethyl ester;2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic Acid Ethyl Ester;Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-, ethyl ester;ethyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate;C19H19ClO4;SCHEMBL12573936;DTXSID70962166;WAROHEJQMZXNDT-UHFFFAOYSA-N;LS-121253;FT-0668495

Chemical Property of Ethyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

Chemical Property:

• Vapor Pressure: 9.36E-09mmHg at 25°C
• Melting Point: 79 °C
• Boiling Point: 463.1°Cat760mmHg
• Flash Point: 167.9°C
• PSA: 52.60000
• Density: 1.197g/cm³
• LogP: 4.29150
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 346.0971868
• Heavy Atom Count: 24
• Complexity: 433

Purity/Quality:

99% ^*data from raw suppliers

FenofibricAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl

Technology Process of Ethyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

There total 2 articles about Ethyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-bromoisobutyrate (600-00-0) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) → 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid ethyl ester (42019-08-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃; Temperature;

Reference yield:

→ 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid ethyl ester (42019-08-9)

Guidance literature:

/BRN= 58973/ in A., TsOH, Δ;

Reference yield:

2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid ethyl ester (42019-08-9) → fenofibric acid (42017-89-0)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 25 ℃; Temperature;

upstream raw materials:

ethyl 2-bromoisobutyrate

4-chloro-4'-hydroxybenzophenone

Downstream raw materials:

fenofibric acid